The National Institutes of Health (NIH) has announced a funding opportunity titled "Intervention Research to Improve Native American Health (R34 Clinical Trial Optional)" aimed at supporting research initiatives that enhance health outcomes in Native American communities. This grant opportunity focuses on developing, adapting, and testing culturally appropriate health promotion and disease prevention interventions, with an emphasis on collaboration with tribal partners to ensure the research is both culturally relevant and scientifically rigorous. The initiative seeks to address significant health disparities faced by Native American populations by fostering local research capacities and developing scalable interventions that align with community values. Grants of up to $450,000 are available over a three-year period, with applications due by January 7, 2027. For further inquiries, interested parties can contact NIH Grants Information at grantsinfo@nih.gov or visit the additional information link at https://grants.nih.gov/grants/guide/pa-files/PAR-23-285.html.

PAR-23-285-Full-Announcement.html

PAR-23-285.html

The Department of Health and Human Services, through the National Institutes of Health (NIH), has announced a funding opportunity (NOFO) aimed at supporting planning and development research to improve health outcomes in Native American communities. The focus is specifically on preparing for clinical trials that address health promotion, disease prevention, and treatment interventions within these populations. This opportunity, denoted by R34, encourages meaningful engagement with tribal partners to ensure culturally appropriate and scientifically rigorous study designs.

The funding allows for grants of up to $450,000 over three years, with an emphasis on pilot studies that test intervention feasibility and cultural acceptability. Applicants must demonstrate collaborative efforts with Native communities and provide clear milestones to justify future trial readiness. This initiative, part of the Intervention Research to Improve Native American Health (IRINAH), seeks to empower local research capacities while addressing health disparities stemming from socio-structural determinants. The main objective is to develop scalable, sustainable interventions that resonate with community values and needs, thereby fostering better health outcomes for Native American populations.

https://grants.nih.gov/grants/guide/pa-files/PAR-23-285.html

The purpose of this funding opportunity announcement (FOA) is to support research on interventions to improve health in Native American (NA) populations. This includes 1) etiologic research, where there is a significant gap in knowledge, that will directly inform intervention development or adaptations, 2) research that develops, adapts, or tests the efficacy or effectiveness of health promotion and disease prevention interventions, 3) research that tests culturally informed treatment or recovery interventions and 4) where a sufficient body of knowledge on intervention efficacy exists, research on dissemination and implementation that develops and tests strategies to overcome barriers to the adoption, integration, scale-up, and sustainability of effective interventions. Existing data suggest that significant acute and chronic disease inequities exist for NA populations. Concurrently, NA populations experience unique sociopolitical, historical, and environmental stressors and risks that may exacerbate health conditions and/or impact the effectiveness of existing solutions to address the conditions. They also possess unique strengths and resiliencies that can mitigate stressors or inform intervention strategies. Through this initiative, intervention and related research is sought to build upon community knowledge, resources, and resilience to test science-based, culturally appropriate solutions to reduce morbidity and mortality through identification and remediation of precursors to diseases and disorders and through culturally informed treatment. Interventions should be designed with a consideration for sustainability within the communities where they are tested, and have the flexibility to be readily adapted, disseminated, and scaled up to other communities where culturally appropriate. For the purposes of this FOA, Native Americans include the following populations: Alaska Natives, American Indians (whose ancestral lands fall at least partially within the U.S. ma

See Section VII. Agency Contacts within the full opportunity announcement for all other inquires.

NIH Grants Information&lt;br/&gt;grantsinfo@nih.gov

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