The National Institutes of Health (NIH) has announced a funding opportunity titled "Intervention Research to Improve Native American Health," aimed at supporting research initiatives that enhance health outcomes in Native American populations. This initiative seeks proposals for R34 Planning Grants that focus on developing and testing culturally appropriate health interventions through community engagement, addressing critical health issues such as substance use, chronic diseases, and mental health disparities. Eligible organizations can request up to $450,000 over three years to conduct research that incorporates Indigenous Knowledge and cultural relevance, with an emphasis on preparing for future clinical trials. Interested applicants should note that the application deadline is January 7, 2027, and can find more information by contacting NIH Grants Information at grantsinfo@nih.gov or visiting the official announcement at https://grants.nih.gov/grants/guide/pa-files/PAR-25-378.html.

PAR-25-378-Full-Announcement.html

PAR-25-378.html

The Department of Health and Human Services, through the National Institutes of Health (NIH), has issued a funding opportunity announcement (NOFO) titled "Intervention Research to Improve Native American Health" aimed at supporting planning and development research to enhance health outcomes in Native American populations. Applicants can submit R34 Planning Grant proposals that include community engagement to adapt and test culturally appropriate health interventions. The initiative encourages partnerships with Native communities, focusing on various health topics, including substance use, chronic diseases, and mental health.

Eligible organizations can request up to $450,000 over three years for direct costs. The funding aims to address significant health disparities faced by Native Americans by fostering scientific rigor in the development of interventions that incorporate Indigenous Knowledge and cultural relevance. Proposals should emphasize the feasibility of future clinical trials and prepare thorough milestone plans for readiness assessment in conducting full-scale trials. Overall, this NOFO represents a targeted effort to develop impactful health strategies while ensuring meaningful engagement with Native American communities.

https://grants.nih.gov/grants/guide/pa-files/PAR-25-378.html

The purpose of this notice of funding opportunity (NOFO) is to support research on interventions to improve health in Native American (NA) populations. This includes 1) etiologic research, where there is a significant gap in knowledge, that will directly inform intervention development or adaptations, 2) research that develops, adapts, or tests the efficacy or effectiveness of health promotion and disease prevention interventions, 3) research that tests culturally informed treatment or recovery interventions and 4) where a sufficient body of knowledge on intervention efficacy exists, research on dissemination and implementation that develops and tests strategies to overcome barriers to the adoption, integration, scale-up, and sustainability of effective interventions. Existing data suggest that significant acute and chronic disease inequities exist for NA populations. Concurrently, NA populations experience unique sociopolitical, historical, and environmental stressors and risks that may exacerbate health conditions and/or impact the effectiveness of existing solutions to address the conditions. They also possess unique strengths and resiliencies that can mitigate stressors or inform intervention strategies. Through this initiative, intervention and related research is sought to build upon community knowledge, resources, and resilience to test science-based, culturally appropriate solutions to reduce morbidity and mortality through identification and remediation of precursors to diseases and disorders and through culturally informed treatment. Interventions should be designed with a consideration for sustainability within the communities where they are tested, and have the flexibility to be readily adapted, disseminated, and scaled up to other communities where culturally appropriate. For the purposes of this NOFO, NA includes the following populations: Alaska Natives, American Indians (whose ancestral lands fall at least partially within the U.S. main land).

See Section VII. Agency Contacts within the full opportunity announcement for all other inquires.

NIH Grants Information&lt;br/&gt;grantsinfo@nih.gov

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