The Department of Health and Human Services announces a funding opportunity through the National Institutes of Health (NIH) aimed at improving health outcomes in Native American populations. This initiative, titled "Intervention Research to Improve Native American Health" (R01 Clinical Trial Optional), encourages research on interventions tailored for health promotion, prevention, treatment, and recovery among Native communities. Eligible applicants include higher education institutions, nonprofit organizations, and tribal governments, with a focus on culturally appropriate research. Applications may address diverse health issues beyond substance use, including cancer, cardiovascular diseases, and mental health. A strong emphasis is placed on community engagement, requiring that researchers work closely with Native communities to ensure cultural appropriateness and sustainability of interventions. The funding aims to build on existing community strengths and utilization of Indigenous Knowledge. The application deadlines span from September 2025 to January 2027, providing researchers with the opportunity to propose impactful studies. This funding opportunity seeks to address health disparities faced by Native Americans and enhance overall community health through rigorous, culturally competent research methods.