The Department of Health and Human Services is announcing a funding opportunity through the National Institutes of Health (NIH) aimed at improving health in Native American populations. This initiative, known as the Intervention Research to Improve Native American Health (IRINAH), encompasses etiologic research, intervention development, and the testing of culturally appropriate health strategies. The opportunity encourages research that identifies, adapts, and disseminates effective interventions tailored to community needs, involving Native American participation in the research process. The funding is specifically intended for projects addressing health disparities related to chronic diseases, substance use, and mental health among Native Americans—including Alaska Natives and Native Hawaiians. Applications for the funding must reflect community engagement and cultural relevance, with an emphasis on sustainability within the communities involved. In addition, the document outlines eligibility requirements, allowable application types, and collaborative expectations between researchers and Native communities. The comprehensive approach aims to enhance health equity and reduce morbidity and mortality rates through informed and effective intervention strategies.