The National Institutes of Health (NIH) is launching the Tribal Undergraduate to Graduate Research Training and Leadership Experiences (TURTLE) Program, aimed at fostering a pool of scientists from American Indian and Alaska Native (AI/AN) communities to conduct research on their health disparities. This funding opportunity encompasses a phased approach, with initial support for capacity-building (UE5) followed by a National Research Service Award (T32) for predoctoral training. Eligible organizations, including federally recognized Tribes and Tribal colleges, may apply for a total of up to seven years of funding. The initiative addresses historical health disparities faced by AI/AN populations and seeks to promote culturally competent research practices. The program's dual focus includes educational development and subsequent implementation of training for doctoral candidates, ensuring they acquire technical and professional skills for careers in biomedical research. The development phase will be closely guided by NIH staff to ensure effective training and mentoring activities, with a strong emphasis on recruiting individuals committed to impacting AI/AN health. Overall, the TURTLE Program reflects NIH's goal of enhancing research workforce diversity while promoting health equity in AI/AN communities.