Catalyze: Product Definition for Small Molecules and Biologics - Target Identification and Validation, and Preliminary Product/Lead Series Identification (R61/R33 Clinical Trials Not Allowed)
ID: 337513Type: Posted
Overview

Buyer

National Institutes of Health (HHS-NIH11)

Eligible Applicants

Others

Funding Category

Health

Funding Instrument

Grant

Opportunity Category

Discretionary

Cost Sharing or Matching Requirement

Yes

Original Source

https://grants.gov/search-results-detail/337513

Additional Information

http://grants.nih.gov/grants/guide/rfa-files/RFA-HL-23-011.html
Timeline
    Description

    The National Institutes of Health (NIH) is offering a funding opportunity titled "Catalyze: Product Definition for Small Molecules and Biologics - Target Identification and Validation, and Preliminary Product/Lead Series Identification (R61/R33 Clinical Trials Not Allowed)." This initiative aims to support early-stage translational research focused on identifying and characterizing therapeutic candidates for heart, lung, blood, and sleep diseases. The program emphasizes a two-phase approach, where the R61 phase involves initial target identification and validation, while the R33 phase focuses on selecting lead candidates for further development, with a requirement for applicants to engage with Accelerator Partners for commercialization expertise. The NIH plans to allocate approximately $6.3 million annually over three years to fund up to 13 new awards, with applications due by December 20, 2024. For further inquiries, interested parties can contact the NIH OER Webmaster at OERWebmaster03@od.nih.gov or visit the additional information link at http://grants.nih.gov/grants/guide/rfa-files/RFA-HL-23-011.html.

    Point(s) of Contact
    OERWebmaster03@od.nih.gov
    Files
    Title
    Posted
    RFA-HL-23-011-Full-Announcement.html
    RFA-HL-23-011.html
    The Department of Health and Human Services, through the National Institutes of Health (NIH) and the National Heart, Lung, and Blood Institute (NHLBI), announces the RFA-HL-23-011 funding opportunity aimed at supporting early-stage translational research for therapeutic candidates addressing heart, lung, blood, and sleep (HLBS) diseases. This Funding Opportunity Announcement (FOA) offers Exploratory/Developmental Phased Awards (R61/R33) to facilitate identification, validation, and preclinical testing of small molecules and biologics. The FOA emphasizes a two-phase approach: the R61 phase focuses on initial target identification and compound validation while the R33 phase emphasizes the selection of lead candidates for further development. Applicants are expected to provide specific project milestones, engage with Accelerator Partners for commercialization expertise, and match at least 0.25:1 of federal funding in the R33 phase. The NIH anticipates allocating approximately $6.3 million annually over three years to fund up to 13 new awards and related opportunities. The applications must comply with detailed submission requirements and will undergo rigorous review based on factors such as significance, investigator qualifications, innovative aspects, approach effectiveness, and project management plans. This initiative seeks to bridge the gap from innovative research to viable therapeutic solutions, enhancing public health outcomes.
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