Catalyze: Product Definition for Small Molecules, Biologics, and Combination Products - Preliminary Product/Lead Series Identification and Combination Product Prototype (R33 - Clinical Trial Not Allowed)
ID: 357337Type: Posted
Overview

Buyer

National Institutes of Health (HHS-NIH11)

Eligible Applicants

Others

Funding Category

Health

Funding Instrument

Grant

Opportunity Category

Discretionary

Cost Sharing or Matching Requirement

Yes

Original Source

https://grants.gov/search-results-detail/357337

Additional Information

http://grants.nih.gov/grants/guide/rfa-files/RFA-HL-26-018.html
Timeline
    Description

    The National Institutes of Health (NIH), through the National Heart, Lung, and Blood Institute (NHLBI), is offering a funding opportunity titled "Catalyze: Product Definition for Small Molecules, Biologics, and Combination Products." This initiative aims to support early-stage translational research focused on identifying lead compounds for therapeutic agents targeting heart, lung, blood, and sleep (HLBS) diseases, facilitating their transition into preclinical testing. Eligible applicants include a diverse range of entities such as higher education institutions, nonprofits, and government bodies, with a requirement for a non-federal cash match of at least 25% of the federal direct costs. The total anticipated funding over three years is approximately $13.4 million, with project budgets capped at $400,000 per year and a maximum project period of two years. Applications must be submitted by December 23, 2027, and further inquiries can be directed to NIH Grants Information at grantsinfo@nih.gov.

    Point(s) of Contact
    grantsinfo@nih.gov
    Files
    Title
    Posted
    RFA-HL-26-018-Full-Announcement.html
    RFA-HL-26-018.html
    The National Institutes of Health (NIH), through the National Heart, Lung, and Blood Institute (NHLBI), is issuing a funding opportunity titled "Catalyze: Product Definition for Small Molecules, Biologics, and Combination Products." This Notice of Funding Opportunity (NOFO) is targeted towards early-stage translational research aimed at identifying lead compounds for the development of therapeutic agents addressing heart, lung, blood, and sleep (HLBS) diseases. The funding goal is to facilitate projects that can transition into preclinical testing with independent support. Eligible entities include higher education institutions, nonprofits, for-profit organizations, and government bodies. Each project must secure a non-federal cash match of at least 25% of the federal direct costs and demonstrate commitment through an Accelerator Partner to aid in commercialization efforts. Key activities supported include lead compound identification, prototype development, and the establishment of intellectual property and regulatory strategies. Importantly, clinical trials are not permitted under this NOFO, and applications will undergo rigorous peer review based on their significance, innovation, rigor, and expertise of the investigators. The total anticipated funding over three years is approximately $13.4 million, with project budgets capped at $400,000 per year and a maximum project period of two years.
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