The Department of Health and Human Services announces a funding opportunity via the NIH for policy research focusing on tobacco, alcohol, and cannabis, particularly how these policies affect use and exposure among disadvantaged populations. The program seeks exploratory research projects to inform equity in cancer prevention through community engagement and collaboration. The funding up to $275,000 over two years aims to enhance health outcomes by examining the influence of federal, state, and local policies on substance use disparities. Key topics of interest include comprehensive smokefree policies, marketing restrictions, pricing interventions, and treatment accessibility. A strong community partnership, diversity in research team perspectives, and a robust dissemination strategy are essential components of each application. The document outlines eligibility, application processes, and evaluation criteria, emphasizing the need for significant involvement from community organizations. The submission deadlines span from early 2025 to 2028. The ultimate goal is to reduce health disparities linked to substance use and promote overall health equity through research-driven policies.