The Department of Health and Human Services, through the National Institutes of Health (NIH), announces a funding opportunity titled "Pilot Health Services and Economic Research on the Treatment of Drug, Alcohol, and Tobacco Use Disorders" (R34 Clinical Trial Optional). This reissue of PA-21-180 encourages pilot studies that prepare for larger-scale effectiveness trials targeting substance use disorder treatments and related services. Funding aims to optimize access, quality, and affordability of these interventions, requiring a focus on diverse perspectives through a Plan for Enhancing Diverse Perspectives (PEDP). Applications for this three-year grant may request up to $450,000 in direct costs, with due dates starting January 16, 2025. Investigators should engage practitioners and assess scalability and sustainability of proposed interventions. Research areas of interest include novel treatment models, implementation strategies, service engagement initiatives, and technology use in service delivery. All applicants must adhere to NIH application instructions and demonstrate inclusivity in their research designs. The peer review process will evaluate proposals based on significance, innovation, rigor, and inclusion efforts. This opportunity reflects a commitment to enhancing personalized substance use treatment and underscores the importance of diversifying perspectives in health research.