The Department of Health and Human Services, through the National Institutes of Health, has issued a Notice of Funding Opportunity (NOFO) titled "Population Approaches to Reducing Alcohol-related Cancer Risk" (PAR-25-221). This initiative seeks to fund interdisciplinary research focused on public awareness and interventions aimed at reducing the risks of alcohol consumption related to cancer. The target areas include changing social norms, evaluating alcohol policy approaches, and developing population-level interventions addressing varying levels of alcohol consumption, particularly among underrepresented minority groups. The funding aims to contribute to better cancer prevention strategies and tackle alcohol-related health disparities, as alcohol is a significant preventable risk factor for various cancers. Applications can be submitted starting January 5, 2025, with deadlines for scientific merit review occurring from February to July 2025. Organizations, including higher education institutions and nonprofits, are encouraged to apply, with a maximum project period of five years. The funding opportunity underscores the necessity of innovative population-based approaches, as traditional individual-level interventions have proven insufficient in mitigating the complexities surrounding alcohol consumption and cancer risk. Overall, this funding initiative represents a commitment to enhancing public health through targeted research and intervention strategies.