The National Institutes of Health (NIH) is preparing to publish a Notice of Funding Opportunity (NOFO) aimed at soliciting applications for pilot and exploratory policy research projects focused on health disparities related to tobacco, alcohol, and cannabis use. The initiative seeks to examine new or adapted policies in the U.S. that address these disparities, with the goal of advancing equitable policies in these areas. This funding opportunity will utilize the R21 grant mechanism, which supports early-stage research, and is expected to be published in September 2024, with the first application due date anticipated in March 2025. Interested applicants are encouraged to participate in a pre-application webinar and can access additional resources, including a presentation and slides, through the provided links. The estimated award date is December 1, 2025, and there is no cost-sharing or matching requirement for applicants.