The National Institutes of Health (NIH) is preparing to publish a Notice of Funding Opportunity (NOFO) for research projects focused on health equity related to tobacco, alcohol, and cannabis policies. This initiative aims to address disparities in exposure and use of these substances by examining new or adapted policies in the U.S., with the goal of advancing equitable health policies. The funding opportunity will utilize the R01 grant mechanism, which is optional for clinical trials, and is expected to be published in September 2024, with the first application due in February 2025. The award ceiling is set at $499,999, and interested applicants are encouraged to participate in a pre-application webinar, with further details to be announced following the NOFO publication.