The National Institutes of Health (NIH) is offering the NIDA Avant-Garde Program for HIV and Substance Use Disorder Research, a federal grant opportunity aimed at funding innovative research that addresses HIV-related issues in the context of substance use disorders. This program seeks exceptionally creative scientists to propose transformative research approaches that diverge from existing projects and align with NIH HIV/AIDS research priorities, ultimately aiming to improve health outcomes for individuals affected by HIV and substance use disorders. Eligible applicants include a wide range of institutions and organizations, with a maximum funding amount of $700,000 per year available for up to five years. Interested parties should submit their applications by August 14, 2025, and can direct inquiries to NIH Grants Information at grantsinfo@nih.gov.