The National Institutes of Health (NIH) is preparing to publish a Notice of Funding Opportunity (NOFO) aimed at enhancing the understanding of the neurological effects associated with infection-related chronic illnesses, including conditions such as Neuro-PASC, post-treatment Lyme Disease, and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). The initiative encourages applications that explore the neurological and psychiatric manifestations of these illnesses, with a particular interest in projects that may investigate common neuropsychiatric mechanisms across multiple conditions, although single-condition studies are also welcome. This funding opportunity, utilizing the R21 activity code, is expected to be announced in Fall 2024, with applications due in Winter 2025, and an estimated award date set for December 1, 2025. Interested applicants should prepare to collaborate and develop responsive projects in advance of the anticipated timeline.