The National Institutes of Health (NIH) plans to publish a Notice of Funding Opportunity (NOFO) for the Rare Diseases Clinical Research Consortia (RDCRC) as part of the Rare Diseases Clinical Research Network (RDCRN). This initiative aims to solicit applications for research that enhances the diagnosis, management, and treatment of rare diseases, promoting collaborative, multi-site, patient-centric, translational, and clinical research. The RDCRC will focus on developing outcome measures that address unmet clinical trial readiness needs, thereby advancing the field of rare disease research. The estimated total program funding is $1,000,000, with the NOFO expected to be published in winter 2024 and applications due in summer 2024. Interested applicants should prepare for a cooperative agreement under the U54 activity code, with an anticipated award date of July 1, 2025.