The National Institutes of Health (NIH) announces funding through the Small Research Grant Program (PA-25-302), aimed at supporting discrete research projects capable of completion within two years and requiring limited funding. Applications, which cannot involve clinical trials, welcome diverse submissions including pilot studies and technological innovation. Funding is capped at $50,000 annually, and organizations must adhere to specific eligibility requirements. Targeted toward higher education institutions, nonprofits, and government entities, the initiative encourages participation by historically underrepresented groups. Key application dates are established, with the first submission opportunity open from January 16, 2025, and continuous review cycles allow for flexibility. Reviewers will assess proposals based on significance, innovation, rigor, feasibility, and investigator qualifications. Compliance with NIH policies and registration in necessary federal systems are prerequisites for applicants. This program reflects NIH's dedication to fostering innovative research that advances public health and scientific knowledge.