The Department of Health and Human Services, through the National Institutes of Health (NIH), is releasing a funding opportunity for the NIH Research Project Grant, designated as the Parent R01 Clinical Trial Required (Funding Opportunity Number PA-25-305). This program supports specified projects within participating NIH Institutes and Centers (ICs) that include at least one proposed clinical trial. The primary aim is to foster innovative research that enhances health, develops scientific resources, and promotes scientific integrity. Key eligibility criteria include a focus on clinical trials, and applications are accepted from various organizations, including higher education institutions, nonprofits, and government entities. The funding is contingent on NIH appropriations, and the maximum project period is five years without specific budget limitations. Applications must comply with NIH's rigorous peer review process, considering factors such as significance, innovation, and the investigator's expertise. Key submission dates are outlined: applications open on January 5, 2025, with due dates for review cycles throughout 2025 and 2026. The opportunity underscores NIH’s commitment to advancing health-related research through the development of substantial, clinically relevant studies.