The National Institutes of Health (NIH) is offering the Research Project Grant (Parent R01 Basic Experimental Studies with Humans Required) to support innovative basic experimental studies involving human participants. This funding opportunity aims to foster research that enhances health outcomes and economic well-being, specifically targeting studies that prospectively assign human participants to conditions to assess biomedical or behavioral outcomes. Eligible applicants include a wide range of institutions, such as historically black colleges, tribal colleges, and foreign organizations, with no cost-sharing requirements. Interested parties should note that applications are due by January 7, 2028, and must comply with registration requirements in SAM and eRA Commons. For further inquiries, applicants can contact NIH Grants Information at grantsinfo@nih.gov or visit the additional information link at https://grants.nih.gov/grants/guide/pa-files/PA-25-303.html.