The National Institutes of Health (NIH), through its National Institute on Drug Abuse (NIDA), is offering a funding opportunity titled the Single Cell Opioid Responses in the Context of HIV (SCORCH) Program, aimed at supporting research on the molecular responses of individual cells related to HIV and substance use disorders (SUD). The program seeks to fund projects that involve data mining of single cell datasets to identify key cellular components and validate their roles in HIV and SUD responses, utilizing innovative techniques such as machine learning and epigenomic manipulations. With an anticipated budget of $3 million over two years, the NIH plans to fund six to seven projects annually, requiring applicants to submit a Plan for Enhancing Diverse Perspectives (PEDP) to promote inclusivity in research. Interested applicants should note that the application period opens on February 19, 2025, and closes on March 20, 2026, with inquiries directed to grantsinfo@nih.gov for further information.