GrantPostedDiscretionary

Integrated Functional Mapping and Molecular Profiling of Cell Ensembles Encoding the Effects of Addictive Substances in Rodents (R01 Clinical Trial Not Allowed)

National Institutes of Health
RFA-DA-25-023
Application Deadline
Feb 23, 2026
Closed
Days Remaining
0
Deadline passed
Award Ceiling
$700,000
Total Program Funding

Grant Opportunity Analysis

The National Institutes of Health (NIH) is offering a funding opportunity titled "Integrated Functional Mapping and Molecular Profiling of Cell Ensembles Encoding the Effects of Addictive Substances in Rodents (R01 Clinical Trial Not Allowed)." This grant aims to support innovative research that utilizes scalable technologies to map and profile cell ensembles related to substance addiction across various exposure stages, including acute, chronic, withdrawal, abstinence, and relapse. The initiative seeks to fill critical gaps in understanding how neural ensembles are activated and how they influence addiction-related behaviors, ultimately contributing to the development of new interventions for substance use disorders. Interested applicants can apply for funding up to $700,000 per year, with a total funding pool of up to $2 million for 1-3 awards, and must submit their applications by February 24, 2026. For further inquiries, applicants can contact NIH Grants Information at grantsinfo@nih.gov or visit the opportunity's webpage at https://grants.nih.gov/grants/guide/rfa-files/RFA-DA-25-023.html.

Eligible Applicants

Others
Additional Eligibility Information

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Grant Documents

2 Files
RFA-DA-25-023-Full-Announcement.html
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AI Summary
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RFA-DA-25-023.html
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AI Summary
The Department of Health and Human Services, specifically the National Institute on Drug Abuse (NIDA), has announced a funding opportunity for research aimed at integrating functional mapping and molecular profiling of cell ensembles related to substance addiction in rodent models. This funding opportunity (RFA-DA-25-023) seeks to address gaps in understanding how neural ensembles are recruited and how they encode addiction-related behaviors. Researchers are encouraged to propose innovative technologies to collect multimodal data on cellular activity and molecular characteristics during various stages of substance exposure, including acute and chronic phases, craving, and relapse. Applications are due by February 24, 2026, with funding totaling up to $2 million for 1-3 awards, and budgets may not exceed $700,000 per year. All projects must avoid clinical trials and adhere to specified application guidelines. Eligible applicants range from higher education institutions to for-profit organizations and foreign entities. The document emphasizes the need for multidisciplinary teams and robust data-sharing plans, ensuring transparency and collaboration within the research community. The ultimate goal is to enhance the scientific understanding of the mechanisms underpinning substance use disorders to inform future interventions and treatments.

Related Grant Opportunities

Project Timeline

postedOriginal Opportunity PostedDec 6, 2023
deadlineApplication DeadlineFeb 23, 2026
expiryArchive DateMar 31, 2026

Funding Details

Award Ceiling
$700,000
No cost sharing required

Agency & Classification

Agency
National Institutes of Health(HHS-NIH11)
Funding Category
Health
Funding Instrument
Grant

Grantor Contact

CFDA Numbers

93.279

Official Sources