Early Stage Testing of Pharmacologic or Device-based Interventions for the Treatment of Mental Disorders (R61/R33 Clinical Trial Required)
ID: 331858Type: Posted
Overview

Buyer

National Institutes of Health (HHS-NIH11)

Eligible Applicants

Others

Funding Category

Health

Funding Instrument

Grant

Opportunity Category

Discretionary

Cost Sharing or Matching Requirement

Yes

Original Source

https://grants.gov/search-results-detail/331858

Additional Information

http://grants.nih.gov/grants/guide/pa-files/PAR-21-137.html
Timeline
    Description

    The National Institutes of Health (NIH), through the National Institute of Mental Health (NIMH), is inviting applications for the Early Stage Testing of Pharmacologic or Device-based Interventions for the Treatment of Mental Disorders (R61/R33 Clinical Trial Required). This funding opportunity aims to support innovative clinical trials that explore novel mechanisms of action in psychiatric treatment, emphasizing a two-phase approach where the R61 phase focuses on milestone-driven testing of target engagement, and the R33 phase extends support for comprehensive studies assessing functional outcomes and safety. The NIH plans to allocate approximately $27 million for this initiative, which is crucial for advancing scientific understanding and clinical practice in mental health. Interested applicants must submit their proposals by October 15, 2024, and can reach out to the NIH OER Webmaster at FBOWebmaster@OD.NIH.GOV for any inquiries regarding the funding announcement.

    Point(s) of Contact
    FBOWebmaster@OD.NIH.GOV
    Files
    Title
    Posted
    PAR-21-137-Full-Announcement.html
    PAR-21-137.html
    The National Institutes of Health (NIH) through the National Institute of Mental Health (NIMH) is soliciting applications for early-stage testing of pharmacological or device-based interventions for mental disorders via the R61/R33 funding opportunity. This program aims to bridge the gap in psychiatric treatment research, encouraging innovative clinical trials focused on unexplored mechanisms of action. The initiative supports two phases: the R61 phase emphasizes milestone-driven testing of target engagement, while the R33 phase extends support for comprehensive studies assessing functional outcomes and safety following initial success. Eligible organizations include higher education institutions, nonprofits, and various government entities, including foreign applicants. The program outlines strict requirements for designing randomized trials, incorporating objective measures of target engagement and considering safety, dosing, and participant recruitment. In total, the NIH plans to allocate approximately $27 million for projects under this funding opportunity, which encourages the exploration of novel interventions that can fulfill critical therapeutic needs in mental health, aiming to advance scientific understanding and clinical practice through rigorous study design and data sharing commitments.
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