The National Institutes of Health (NIH), through the National Institute of Mental Health (NIMH), is inviting applications for the funding opportunity titled "Pilot Effectiveness Trials for Post-Acute Interventions and Services to Optimize Longer-term Outcomes" (PAR-25-206). This initiative aims to evaluate the preliminary effectiveness of therapeutic and service delivery interventions for the post-acute management of mental health conditions, focusing on aspects such as feasibility, tolerability, acceptability, safety, and potential effectiveness. The program is crucial for advancing mental health treatment and understanding, particularly for underserved populations, by gathering data that will inform larger-scale effectiveness trials. Interested applicants can apply for grants of up to $750,000 over a three-year period, with the submission window opening on January 5, 2025, and closing on January 7, 2028. For more information, applicants can contact NIH Grants Information at grantsinfo@nih.gov or visit the official announcement at https://grants.nih.gov/grants/guide/pa-files/PAR-25-206.html.