The Department of Health and Human Services, specifically through the National Institutes of Health (NIH), has released a funding opportunity titled "NINDS Exploratory Clinical Trials for Small Business" targeting Small Business Concerns (SBCs). This initiative supports Phase I and II exploratory clinical trials focused on neurological disorders, facilitating the development of drugs, devices, or therapies. The program emphasizes the importance of diverse research teams and requires a Plan for Enhancing Diverse Perspectives (PEDP) for applications. Key dates for application submission start on December 5, 2023, with funding amounts capped at $295,924 for Phase I and $1,972,828 for Phase II projects. Proposals must align with NINDS goals and address existing gaps in clinical research, ultimately aiming for commercialization. The NOFO's structure provides guidance on eligibility, project proposals, application requirements, and collaboration with third-party investors to help bridge the gap for small firms in clinical trial funding, reinforcing NIH’s commitment to fostering inclusive, innovative research in the biomedical field.