The Joint NINDS/NIMH Exploratory Neuroscience Research Grant program, issued by the National Institutes of Health (NIH), supports innovative and exploratory research in neuroscience without allowing clinical trials. The program focuses on early-stage projects that could potentially lead to significant advancements in understanding neuroscience or the development of new methodologies. Applicants are advised to ensure their proposals align with the missions of the National Institute of Neurological Disorders and Stroke (NINDS) and the National Institute of Mental Health (NIMH) and to consult with relevant program staff before submission. Eligible for funding are various educational institutions, nonprofits, governmental organizations, foreign entities, and small businesses, with awards limited to $275,000 over two years. All applications must adhere to strict submission guidelines, including data management and sharing plans. Key deadlines begin with an application opening on January 16, 2025, and awards anticipated by July 2025. The rigorous review process includes considerations of scientific merit, innovation, and expertise of the investigators. This program underscores NIH's commitment to fostering groundbreaking research in neuroscience while ensuring adherence to regulatory standards and maximizing potential for impactful discoveries.