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The Department of Health and Human Services has released a Notice of Funding Opportunity (NOFO) aimed at supporting early-career scientists and health professionals in transitioning to entrepreneurship via the Small Business Transition Grant (R41/R42), which mandates the inclusion of clinical trials. The funding initiative from the National Institutes of Health encourages small business concerns (SBCs) to employ and develop researchers as Program Directors/Principal Investigators (PDs/PIs) while fostering their entrepreneurial skills through mentorship and entrepreneurial training. Key components include identifying a mentor with entrepreneurial experience, creating a career development plan for the PD/PI, and ensuring the scientific relevance of proposed projects aligned with the participating institutes. Eligibility is limited to individuals with limited prior entrepreneurial experience, promoting inclusion particularly from underrepresented groups in biomedical research. The grant supports both Phase I and Fast-Track proposals, with Phase I focusing on establishing technical feasibility and Phase II targeting product commercialization. The structure allows for comprehensive training and development, vital for transforming scientific innovation into viable businesses, reflecting NIH's commitment to fostering a diverse and skilled biomedical workforce while advancing healthcare technologies.