HEAL Initiative: INTERACT INTEgRAtive Back Pain Longitudinal Cohort Teams (UC2 Clinical Trial Optional)
ID: 355568Type: Posted
Overview

Buyer

National Institutes of Health (HHS-NIH11)

Eligible Applicants

Others

Funding Category

Health

Funding Instrument

Cooperative Agreement

Opportunity Category

Discretionary

Cost Sharing or Matching Requirement

Yes

Original Source

https://grants.gov/search-results-detail/355568

Additional Information

http://grants.nih.gov/grants/guide/rfa-files/RFA-AR-25-005.html
Timeline
    Description

    The National Institutes of Health (NIH) has announced a funding opportunity under the HEAL Initiative for interdisciplinary teams to enhance longitudinal data collection related to chronic low back pain (cLBP). The objective is to solicit cooperative agreement applications that will expand existing cLBP cohort studies, focusing on understanding pain mechanisms and improving personalized pain management strategies. This initiative is crucial in addressing the opioid crisis and advancing pain management through rigorous scientific research. A total funding of $5 million is available for FY 2025, with an expected $11 million annually for FY 2026-2029, aiming to grant 2-3 awards. Interested applicants must submit their proposals by October 11, 2024, and can direct inquiries to grantsinfo@nih.gov for further information.

    Point(s) of Contact
    grantsinfo@nih.gov
    Files
    Title
    Posted
    RFA-AR-25-005-Full-Announcement.html
    RFA-AR-25-005.html
    The NIH’s Helping to End Addiction Long-term (HEAL) Initiative has launched a Notice of Funding Opportunity (NOFO) for interdisciplinary teams to enhance longitudinal data collection related to chronic low back pain (cLBP). This initiative invites research teams to expand on existing cLBP cohort studies, aiming to improve diagnosis and treatment through advanced understanding of chronic pain mechanisms. The application is open from September 11, 2024, with a total funding of $5 million in FY 2025 and $11 million annually for FY 2026-2029 expected to grant 2-3 awards. Applications must address several key research questions, including understanding molecular pain mechanisms, the role of various tissues in pain generation, and optimal personalized pain management strategies. Diversity is emphasized, requiring a Plan for Enhancing Diverse Perspectives (PEDP) to encourage diverse research teams and participant recruitment. The initiative promotes cooperation among awardees through regular meetings, data sharing, and development of collaborative research efforts. To apply, eligible organizations must meet specific requirements and follow detailed submission instructions. The selection will focus on scientific merit, investigator competence, innovative approaches, and the anticipated impact on advancing cLBP research. This NOFO is an essential part of a broader strategy to combat the opioid crisis and enhance pain management through scientifically rigorous approaches.
    Similar Opportunities
    HEAL Initiative: Interdisciplinary Team Science to Uncover the Mechanisms of Pain Relief by Medical Devices (RM1 Clinical Trial Optional)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH) has announced a funding opportunity titled "HEAL Initiative: Interdisciplinary Team Science to Uncover the Mechanisms of Pain Relief by Medical Devices," aimed at addressing the opioid epidemic by promoting innovative research into alternative pain management solutions. This initiative seeks interdisciplinary research teams composed of multiple Principal Investigators (PDs/PIs) to explore the mechanisms of action of FDA-approved medical devices designed for pain relief, with the goal of optimizing therapeutic outcomes and enhancing understanding of device-based therapies. With over 25 million Americans suffering from chronic pain, this funding is critical for developing safe and effective pain treatment options that minimize addiction risks. Interested applicants can apply for grants with an award ceiling of $1.5 million, and proposals are due by June 9, 2025. For further inquiries, applicants may contact NIH Grants Information at grantsinfo@nih.gov or visit the opportunity's webpage at https://grants.nih.gov/grants/guide/rfa-files/RFA-NS-23-028.html.
    NIH HEAL Initiative: Coordinated Approaches to Pain Care in Health Care Systems (UG3/UH3 - Clinical Trial Optional)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity under the HEAL Initiative for the implementation of coordinated pain care models within healthcare systems that currently lack such frameworks. This initiative encourages applications for UG3/UH3 phased cooperative agreements that utilize implementation science to enhance multidisciplinary chronic pain management, particularly focusing on populations with significant health disparities. The program aims to foster structured collaborations among healthcare providers, patients, and policymakers to improve access to comprehensive care, with an expected budget of approximately $4 million to fund 3 to 5 projects. Interested applicants must submit their proposals by November 8, 2024, and can find additional information and submission guidelines at the NIH grants website or contact NIH Grants Information at grantsinfo@nih.gov.
    HEAL Initiative: Understanding Individual Differences in Human Pain Conditions (R01 - Clinical Trial Optional)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity under the HEAL Initiative aimed at understanding individual differences in human pain conditions through the R01 grant mechanism. This initiative seeks research proposals that focus on the holistic understanding of pain variability among individuals, emphasizing the collection of clinical and preclinical data to inform personalized pain management strategies. The program is particularly relevant in the context of addressing the ongoing opioid crisis and aims to foster innovative, evidence-based solutions for pain treatment by encouraging multidisciplinary approaches and patient engagement. Approximately $4 million is available to support 3-4 awards, with applications due by February 6, 2025. Interested applicants can find more information and application guidelines at the NIH grants website or contact NIH Grants Information at grantsinfo@nih.gov.
    HEAL Initiative: Development of Therapies and Technologies Directed at Enhanced Pain Management (R41/R42 Clinical Trial Not Allowed)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH) has announced a funding opportunity titled "HEAL Initiative: Development of Therapies and Technologies Directed at Enhanced Pain Management," aimed at addressing the national opioid public health crisis. This initiative encourages small businesses to develop innovative, non-addictive therapies and technologies for improved pain management, including new medications, pain-assessment devices, and treatment strategies for chronic pain. The funding available includes up to $275,766 for Phase I and $1,838,436 for Phase II grants, with applications due by April 4, 2025. Interested applicants can find more information and guidelines at the NIH grants website or contact NIH Grants Information at grantsinfo@nih.gov.
    HEAL Initiative: HEAL KIDS (Knowledge, Innovation and Discovery Studies): Chronic Pain Program (UC2 Clinical Trial Optional)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity under the HEAL Initiative, specifically targeting chronic pain in children and adolescents through the HEAL KIDS Chronic Pain Program. This program invites interdisciplinary research teams to conduct innovative studies that integrate clinical research, advanced technologies, and measurement science to enhance understanding and management of chronic pain conditions in youth. The initiative emphasizes the importance of diversity in research, requiring applicants to submit a Plan for Enhancing Diverse Perspectives, and aims to improve pediatric pain management and facilitate clinical trials. Approximately $5 million is available for 2-3 awards, with a maximum annual budget of $1.3 million over a five-year project period. Interested applicants must submit their proposals by November 8, 2024, and can find additional information at NIH Grants or contact NIH Grants Information at grantsinfo@nih.gov for further inquiries.
    HEAL Initiative: Non-addictive Analgesic Therapeutics Development [Small Molecules and Biologics] to Treat Pain (UG3/UH3 Clinical Trial Optional)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity under the HEAL Initiative to support the development of non-addictive analgesic therapeutics, specifically small molecules and biologics, aimed at treating pain. The initiative seeks to accelerate the optimization and transition of promising therapeutic candidates to Phase I clinical trials, requiring applicants to demonstrate a compelling biological rationale and suitable assays for their projects. This funding is crucial for addressing the needs of over 25 million Americans suffering from chronic pain while providing alternatives to opioids. Approximately $11 million is anticipated for distribution across four awards in FY 2024, with applications due by January 24, 2024. For further inquiries, interested parties can contact NIH Grants Information at grantsinfo@nih.gov.
    HEAL Initiative: Studies to Enable Analgesic Discovery (R61/R33 - Clinical Trial Not Allowed)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity through the HEAL Initiative aimed at supporting research for non-opioid analgesics via the R61/R33 Exploratory/Developmental Phased Award. This initiative encourages applications that focus on the early translational steps in developing novel pain treatment strategies, including the development and validation of assays and the identification of potential therapeutic agents, while explicitly prohibiting clinical trials. The funding amount is up to $350,000 per year, with a total project period not exceeding three years, and applications are due by January 15, 2027. Interested applicants can find more information and application guidelines at the NIH grants website or contact NIH Grants Information at grantsinfo@nih.gov for further inquiries.
    HEAL Initiative-Early-Stage Discovery of New Pain Targets Within the Understudied Druggable Proteome (R03 Clinical Trial Not Allowed)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH) is inviting applications for the HEAL Initiative's funding opportunity titled "Early-Stage Discovery of New Pain Targets Within the Understudied Druggable Proteome (R03 Clinical Trial Not Allowed)." This initiative aims to support pilot projects that identify new druggable targets for pain by generating preliminary data on understudied proteins associated with pain management. The funding opportunity is particularly significant as it seeks to advance research in pain management and drug discovery, contributing to the broader goal of addressing the opioid addiction crisis. Eligible applicants can receive up to $100,000 for projects lasting one year, with applications due by July 16, 2026. For further inquiries, interested parties can contact NIH Grants Information at grantsinfo@nih.gov or visit the additional information link at https://grants.nih.gov/grants/guide/pa-files/PAR-24-197.html.
    HEAL Initiative: Discovery and Validation of Novel Targets for Safe and Effective Pain Treatment (R01 Clinical Trial Not Allowed)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity under the HEAL Initiative aimed at discovering and validating novel therapeutic targets for safe and effective pain treatment through the R01 Clinical Trial Not Allowed grant. This initiative seeks proposals that focus on basic science research targeting the peripheral nervous system, central nervous system, and other tissues, with an emphasis on developing pain therapeutics that minimize side effects and addiction risks. The NIH plans to award 8-10 grants, with project durations of up to five years, addressing various pain conditions including acute and chronic pain syndromes, amidst the ongoing opioid crisis. Interested applicants must submit their proposals by December 6, 2024, and can find additional information and submission guidelines at the provided NIH link or contact the NIH OER Webmaster at OERWebmaster03@od.nih.gov.
    HEAL INITIATIVE: Development of Therapies and Technologies Directed at Enhanced Pain Management (R43/R44 Clinical Trial Not Allowed)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity through the HEAL Initiative aimed at developing innovative therapies and technologies for enhanced pain management. This initiative specifically seeks applications from small businesses focused on creating non-addictive pain treatment alternatives, objective pain measurement tools, and new screening methodologies to address the national opioid crisis. With an annual funding projection of up to $8 million for 5-15 awards, eligible applicants must be U.S. small businesses, and the application deadline is set for April 4, 2025. For further inquiries, interested parties can contact NIH Grants Information at grantsinfo@nih.gov or visit the opportunity's webpage at https://grants.nih.gov/grants/guide/rfa-files/RFA-NS-23-006.html.