The National Institutes of Health (NIH) is offering a funding opportunity under the HEAL Initiative, titled "Studies to Enable Analgesic Discovery (R61/R33 - Clinical Trial Not Allowed)," aimed at developing non-opioid, non-addictive therapies for pain management. This grant supports exploratory and developmental research focused on drug discovery, including the validation of assays and identification of therapeutic agents such as small molecules, biologics, and natural products, in response to the ongoing opioid crisis. The total funding anticipated for FY 2025 is $2.5 million, with 4-5 awards expected, and applications are due by January 15, 2027. Interested applicants can find more information and contact NIH Grants Information at grantsinfo@nih.gov for inquiries.