The National Institutes of Health (NIH) is offering a funding opportunity through the HEAL Initiative titled "Understanding Individual Differences in Human Pain Conditions" (R01 - Clinical Trial Optional). This initiative aims to support research that explores the diverse factors influencing chronic pain, emphasizing a holistic approach to enhance personalized pain management strategies. The program encourages multidisciplinary research that collects clinical and preclinical data to model inter-individual differences in pain and related comorbidities, including mental health and substance use issues, while actively involving patients and caregivers in the research process. Approximately $4 million is anticipated for up to four awards, with applications due by February 6, 2025. Interested applicants can find more information and contact NIH Grants Information at grantsinfo@nih.gov or visit the additional information link at https://grants.nih.gov/grants/guide/rfa-files/RFA-NS-24-021.html.