The National Institutes of Health (NIH) is announcing a funding opportunity for research on the impact of environmental exposures on gut-brain signaling in neurological conditions through the R01 grant mechanism. This initiative aims to enhance understanding of the gut microbiome-brain axis to develop intervention strategies for neurological diseases influenced by environmental factors, including mental health disorders and neurodegenerative conditions like Parkinson's and Alzheimer's diseases. The program is expected to allocate approximately $4 million across eight awards, with applications anticipated to open following the publication of a Notice of Funding Opportunity (NOFO) in late October 2025, and the estimated project start date is set for July 1, 2026. Interested researchers are encouraged to contact Dr. Anika L. Dzierlenga at anika.dzierlenga@nih.gov or call 984-287-3125 for further information.