Development of Animal Models and Related Biological Materials for Down Syndrome Research (R24 Clinical Trials Not-Allowed)
ID: 344038Type: Posted
Overview

Buyer

National Institutes of Health (HHS-NIH11)

Eligible Applicants

Others

Funding Category

Income Security and Social Services

Funding Instrument

Grant

Opportunity Category

Discretionary

Cost Sharing or Matching Requirement

Yes

Original Source

https://grants.gov/search-results-detail/344038

Additional Information

http://grants.nih.gov/grants/guide/pa-files/PAR-22-247.html
Timeline
    Description

    The National Institutes of Health (NIH) has announced a funding opportunity titled "Development of Animal Models and Related Biological Materials for Down Syndrome Research," aimed at enhancing research related to Down syndrome (DS) through the INCLUDE Project. This initiative seeks grant applications focused on developing and characterizing animal models and biological materials that can significantly contribute to understanding the biological mechanisms of DS, utilizing advanced technologies such as artificial intelligence and machine learning. The NIH plans to allocate $1.5 million annually from FY2023 to FY2026, supporting at least two projects each year, with a maximum project duration of four years. Interested applicants can find more information and submission guidelines at the NIH Grants website and should direct inquiries to grantsinfo@nih.gov.

    Point(s) of Contact
    grantsinfo@nih.gov
    Files
    Title
    Posted
    PAR-22-247-Full-Announcement.html
    PAR-22-247.html
    The National Institutes of Health (NIH) has announced a funding opportunity aimed at developing animal models and related biological materials for Down syndrome (DS) research, under the INCLUDE Project. This initiative addresses the health challenges faced by individuals with DS, which is the most common genetic cause of intellectual disability, and aims to improve health outcomes and quality of life. NIH plans to allocate $1.5 million annually from FY2023 to FY2026, supporting at least two awarded projects each year, with a maximum project duration of four years. Eligible applicants include higher education institutions, nonprofits, and various governmental bodies. The application process includes strict adherence to submission guidelines, which must be prepared using the NIH's ASSIST system or Grants.gov. Projects should focus on innovative animal model development that enhances understanding of biological mechanisms, genetic resources, and application of advanced technologies such as AI and ML to improve preclinical research. The NIH emphasizes the importance of collaboration and resource sharing to advance DS research, while strictly enforcing compliance with applicable ethical and humanitarian standards throughout the research process. Overall, this funding opportunity seeks to bolster research that contributes significantly to the knowledge of Down syndrome and its associated conditions.
    Similar Opportunities
    Development of Animal Models and Related Biological Materials for Down Syndrome Research (R21 Clinical Trials Not Allowed)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH) has announced a funding opportunity titled "Development of Animal Models and Related Biological Materials for Down Syndrome Research" under the INCLUDE Project. This initiative aims to support exploratory and innovative research focused on developing and characterizing animal models and biological materials that are essential for Down syndrome (DS) studies, with an emphasis on improving access to these resources and enhancing the rigor of preclinical research. The funding opportunity is particularly significant as it addresses critical gaps in DS research, encouraging projects that utilize advanced technologies such as artificial intelligence and machine learning. Eligible applicants can receive up to $200,000 for a two-year project period, with applications due in March, June, October, and February each year, and the announcement set to expire on January 8, 2026. For further inquiries, interested parties can contact NIH Grants Information at grantsinfo@nih.gov.
    INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Clinical Research Short Course (R25 Independent Clinical Trial Not Allowed)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH) has announced a funding opportunity titled "INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE)," aimed at enhancing the clinical research workforce focused on Down syndrome (DS) and its associated health conditions. This initiative encourages the development of innovative short courses designed to equip graduate students and early-career professionals with essential clinical research skills, thereby improving the understanding of DS and fostering the development of new treatments. The program offers funding of up to $400,000 annually for a potential duration of five years, with a strong emphasis on outreach to underrepresented groups in biomedical sciences. Interested applicants can find more information and apply by September 7, 2025, by contacting NIH Grants Information at grantsinfo@nih.gov or visiting the official announcement at https://grants.nih.gov/grants/guide/pa-files/PAR-22-195.html.
    Omics Phenotypes Related to Down Syndrome for the INCLUDE Project (X01 Clinical Trial Not Allowed)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH) has announced a Notice of Funding Opportunity (NOFO) titled "Omics Phenotypes Related to Down Syndrome for the INCLUDE Project (X01 Clinical Trial Not Allowed)." This initiative invites applications to utilize existing biospecimens to generate integrated genomic and multi-omics data aimed at uncovering the molecular mechanisms associated with health conditions related to Down syndrome. The program emphasizes the importance of including cohorts from underrepresented racial and ethnic groups and does not provide direct funding; instead, it facilitates access to sequencing resources for various genomic profiling techniques. Interested applicants should note that the earliest submission date is February 13, 2024, and they can reach out to NIH Grants Information at grantsinfo@nih.gov for further inquiries. More details can be found at the provided link: https://grants.nih.gov/grants/guide/pa-files/PAR-24-081.html.
    INCLUDE (INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE) Predoctoral to Postdoctoral Fellow Transition Award (F99/K00 Clinical Trial Not Allowed)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH) is offering the INCLUDE (INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE) Predoctoral to Postdoctoral Fellow Transition Award (F99/K00), aimed at recruiting exceptional graduate students for Down syndrome-related research. This opportunity invites interdisciplinary applications from diverse fields such as genetics, biochemistry, data science, imaging, engineering, and neurobiology, providing two phases of support: the F99 phase for 1-2 years of dissertation research, followed by the K00 phase for up to 4 years of mentored postdoctoral training. The NIH plans to commit $1.5 million in FY2025 for up to 20 awards, contingent on the quality of applications, with a submission deadline of July 1, 2026. Interested applicants are encouraged to contact the NIH Grants Information at grantsinfo@nih.gov for further inquiries and to review the full announcement at NIH Grants.
    Development of Animal Models and Related Biological Materials for Research (R21 Clinical Trial Not Allowed)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH) is offering the R21 Exploratory/Developmental Research Grant (PAR-21-167) to support innovative research aimed at developing animal models and related biological materials for biomedical studies. This funding opportunity encourages projects that enhance understanding of human health and diseases by creating models that evaluate multiple body systems or diseases affecting them, rather than focusing on a single disease or NIH Institute. With a funding ceiling of $200,000 available for direct costs over a maximum project duration of two years, eligible applicants include higher education institutions, non-profits, and various governmental organizations. The application deadline is January 7, 2025, and interested parties can reach out to the NIH OER Webmaster at FBOWebmaster@OD.NIH.GOV for further inquiries.
    Resource-Related Research Projects for Development of Animal Models and Related Materials (R24 Clinical Trials Not-Allowed)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity titled "Resource-Related Research Projects for Development of Animal Models and Related Materials," aimed at advancing research that develops and enhances animal models relevant to human diseases. The initiative seeks applications that demonstrate the need for and potential impact of broadly applicable resources across multiple NIH Institutes and Centers, emphasizing projects that address diseases affecting multiple body systems rather than those focused on specific diseases or singular NIH interests. Eligible applicants include higher education institutions, nonprofit organizations, and government agencies, with funding available up to $5 million per year. The application deadline is set for January 25, 2025, and interested parties can reach out to NIH Grants Information at grantsinfo@nih.gov for further inquiries.
    Development of Animal Models and Related Materials for HIV/AIDS Research (R24 Clinical Trials Not Allowed)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH) is inviting applications for the development of animal models and related materials for HIV/AIDS research through a federal grant opportunity titled "Development of Animal Models and Related Materials for HIV/AIDS Research (R24 Clinical Trials Not Allowed)." This initiative aims to support projects that enhance existing animal models or create new ones that are broadly applicable across multiple NIH Institutes and Centers, focusing on various body systems to align with NIH's research priorities in HIV/AIDS. The opportunity is significant for advancing scientific knowledge and therapeutic strategies in the field, with applications due by January 7, 2025. Interested applicants can find more information and submit inquiries via email at grantsinfo@nih.gov or visit the additional information link at https://grants.nih.gov/grants/guide/pa-files/PAR-22-204.html.
    Development and Validation of Human Cellular Models for Alzheimer's Disease-Related Dementias (ADRD) (R01 - Clinical Trial Not Allowed)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity for the development and validation of human cellular models for Alzheimer's Disease-Related Dementias (ADRD) through the R01 Research Project Grant mechanism. This initiative aims to create novel and complex cellular models that accurately reflect the multifaceted pathologies and various cell types associated with ADRD, with a strong emphasis on validation against human data to ensure scientific rigor. The total funding commitment for this opportunity is anticipated to be up to $4.5 million for FY2025, with individual project budgets capped at $500,000 in direct costs annually for a maximum duration of five years. Interested applicants can find more details and guidelines in the full announcement available at NIH Grants, and inquiries can be directed to grantsinfo@nih.gov. The application deadline is October 21, 2024.
    Advancing Research to Understand Congenital Malformations (R01 Clinical Trial Not Allowed)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity titled "Advancing Research to Understand Congenital Malformations (R01 Clinical Trial Not Allowed)" aimed at supporting innovative research into the mechanisms underlying structural birth defects. This grant encourages applicants to utilize animal models alongside human translational and clinical approaches, focusing on genetic, epigenetic, and environmental factors that contribute to these conditions. With over 120,000 infants affected annually in the U.S., this research is critical for public health, and projects may receive funding of up to $499,999 per year for a maximum of five years. Interested applicants must submit their proposals by September 7, 2025, and can direct inquiries to NIH Grants Information at grantsinfo@nih.gov or visit the opportunity's webpage for more details at https://grants.nih.gov/grants/guide/pa-files/PAR-22-215.html.
    Research Projects to Enhance Applicability of Mammalian Models for Translational Research (R01 Clinical Trial Not Allowed)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH) has announced a funding opportunity titled "Research Projects to Enhance Applicability of Mammalian Models for Translational Research (R01 Clinical Trial Not Allowed)." This initiative invites applications aimed at improving the utility of mammalian cancer models, including organoids and tumoroids, to better represent human biology and address translational deficiencies in existing models. The funding seeks to advance cancer research by fostering innovative approaches to validate these models and enhance their clinical relevance, ultimately aiming to improve patient outcomes. Eligible applicants can receive up to $499,000 per year for a maximum of five years, with applications due by September 7, 2026. For further inquiries, interested parties can contact NIH Grants Information at grantsinfo@nih.gov or visit the additional information link at https://grants.nih.gov/grants/guide/pa-files/PAR-23-281.html.