Omics Phenotypes Related to Down Syndrome for the INCLUDE Project (X01 Clinical Trial Not Allowed)
ID: 351318Type: Posted
Overview

Buyer

National Institutes of Health (HHS-NIH11)

Eligible Applicants

Others

Funding Category

Income Security and Social Services

Funding Instrument

Grant

Opportunity Category

Discretionary

Cost Sharing or Matching Requirement

Yes

Original Source

https://grants.gov/search-results-detail/351318

Additional Information

http://grants.nih.gov/grants/guide/pa-files/PAR-24-081.html
Timeline
    Description

    The National Institutes of Health (NIH) is inviting applications for the INCLUDE Project, aimed at generating integrated genomic and multi-omics data related to Down syndrome. This initiative seeks to elucidate the molecular mechanisms behind health conditions associated with Down syndrome by encouraging the submission of existing biospecimens for various omics analyses, including whole genome sequencing and other advanced techniques. The project emphasizes the importance of broad data sharing and aims to enhance understanding of co-occurring conditions to improve health outcomes for affected individuals, with no direct funding provided to applicants. Interested parties should note that the application deadline is March 13, 2026, and can find more information at the NIH Grants website or contact NIH Grants Information at grantsinfo@nih.gov for inquiries.

    Point(s) of Contact
    grantsinfo@nih.gov
    Files
    Title
    Posted
    PAR-24-081-Full-Announcement.html
    PAR-24-081.html
    The Department of Health and Human Services, through the NIH, invites applications for the INCLUDE Project, focusing on generating integrated genomic and multi-omics data related to Down syndrome. This initiative aims to elucidate the molecular mechanisms behind health issues associated with Down syndrome, which affects a significant number of individuals annually. The program encourages biospecimen submissions for diverse omics analyses, including genome sequencing and other advanced techniques, with a strong emphasis on underrepresented groups. No direct funding will be provided to applicants under this notice; instead, selected cohorts will gain access to NIH resources to support data generation. Overall, the project seeks to enhance understanding of Down syndrome's co-occurring conditions and improve health outcomes for affected individuals through collaborative efforts with designated sequencing centers. Key dates for application submissions are outlined, with a project period not exceeding one year. Eligibility encompasses various institutions and organizations, emphasizing the importance of broad data sharing for research advancement.
    Similar Opportunities
    Development of Animal Models and Related Biological Materials for Down Syndrome Research (R24 Clinical Trials Not-Allowed)
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity for the development of animal models and related biological materials aimed at advancing Down syndrome (DS) research as part of the INCLUDE Project. This initiative seeks to enhance understanding of DS and its co-occurring conditions by fostering innovative research that includes the creation of genetic resources, advanced informatics technologies such as artificial intelligence, and improved rigor in preclinical studies. With a total budget of $1.5 million anticipated for fiscal years 2023-2026, the NIH plans to fund at least two awards per year, with applications due by May 25, 2025. Interested applicants can find more information and submission guidelines at the NIH grants website or contact NIH Grants Information at grantsinfo@nih.gov.
    Development of Animal Models and Related Biological Materials for Down Syndrome Research (R21 Clinical Trials Not Allowed)
    National Institutes of Health
    The National Institutes of Health (NIH) has announced a funding opportunity titled "Development of Animal Models and Related Biological Materials for Down Syndrome Research" under the INCLUDE Project. This initiative aims to support exploratory and innovative research focused on developing and characterizing animal models and biological materials that are essential for Down syndrome (DS) studies, with an emphasis on improving access to these resources and enhancing the rigor of preclinical research. The funding opportunity is particularly significant as it addresses critical gaps in DS research, encouraging projects that utilize advanced technologies such as artificial intelligence and machine learning. Eligible applicants can receive up to $200,000 for a two-year project period, with applications due in March, June, October, and February each year, and the announcement set to expire on January 8, 2026. For further inquiries, interested parties can contact NIH Grants Information at grantsinfo@nih.gov.
    Development of Animal Models and Related Biological Materials for Down Syndrome Research (R21 Clinical Trial Not Allowed)
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity for exploratory research grants (R21) aimed at developing animal models and biological materials for Down syndrome (DS) research. This initiative, part of the INCLUDE Project, seeks to enhance understanding of co-occurring conditions associated with DS and improve health outcomes for affected individuals through innovative research. Eligible applicants, including higher education institutions, nonprofits, and local governments, can request up to $200,000 for a single year, with a total project period not exceeding two years. Interested parties should submit their applications by January 7, 2026, and can direct inquiries to NIH Grants Information at grantsinfo@nih.gov.
    INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Clinical Research Short Course (R25 Independent Clinical Trial Not Allowed)
    National Institutes of Health
    The National Institutes of Health (NIH) has announced a funding opportunity titled "INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE)," aimed at enhancing the clinical research workforce focused on Down syndrome (DS) and its associated health conditions. This initiative encourages the development of innovative short courses designed to equip graduate students and early-career professionals with essential clinical research skills, thereby improving the understanding of DS and fostering the development of new treatments. The program offers funding of up to $400,000 annually for a potential duration of five years, with a strong emphasis on outreach to underrepresented groups in biomedical sciences. Interested applicants can find more information and apply by September 7, 2025, by contacting NIH Grants Information at grantsinfo@nih.gov or visiting the official announcement at https://grants.nih.gov/grants/guide/pa-files/PAR-22-195.html.
    INCLUDE (INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE) Predoctoral to Postdoctoral Fellow Transition Award (F99/K00 Clinical Trial Not Allowed)
    National Institutes of Health
    The National Institutes of Health (NIH) is offering the INCLUDE (INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE) Predoctoral to Postdoctoral Fellow Transition Award (F99/K00), aimed at recruiting exceptional graduate students for Down syndrome-related research. This opportunity invites interdisciplinary applications from diverse fields such as genetics, biochemistry, data science, imaging, engineering, and neurobiology, providing two phases of support: the F99 phase for 1-2 years of dissertation research, followed by the K00 phase for up to 4 years of mentored postdoctoral training. The NIH plans to commit $1.5 million in FY2025 for up to 20 awards, contingent on the quality of applications, with a submission deadline of July 1, 2026. Interested applicants are encouraged to contact the NIH Grants Information at grantsinfo@nih.gov for further inquiries and to review the full announcement at NIH Grants.
    Investigator Initiated Innovation in Computational Genomics and Data Science (R01 Clinical Trial Not Allowed)
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity titled "Investigator Initiated Innovation in Computational Genomics and Data Science (R01 Clinical Trial Not Allowed)" aimed at supporting innovative research in computational genomics and data science. This initiative encourages applications that focus on developing novel analytical methodologies, tools, and software that can be broadly applied to enhance human health and disease understanding, with an emphasis on scalable systems for managing complex genomic data. Eligible applicants include a wide range of organizations such as higher education institutions, nonprofits, and tribal colleges, with a maximum budget of $500,000 per year available for projects lasting up to five years. The application submission period opens on January 6, 2025, and closes on September 7, 2027. For further inquiries, interested parties can contact NIH Grants Information at grantsinfo@nih.gov.
    Investigator Initiated Innovation in Computational Genomics and Data Science (R21 Clinical Trial Not Allowed)
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity titled "Investigator Initiated Innovation in Computational Genomics and Data Science (R21 Clinical Trial Not Allowed)" aimed at advancing research in computational genomics, bioinformatics, and data visualization methodologies that enhance genomic science and its application to human health. This initiative seeks innovative projects that develop novel analytical tools and methodologies, with a budget limit of $275,000 for a two-year project period, focusing on scalable solutions applicable across various diseases and biological systems. The funding is particularly targeted at underrepresented entities in genomic research, including higher education institutions, nonprofits, and governmental bodies, reflecting NIH's commitment to fostering collaborative research in this critical field. Interested applicants should note that key submission dates begin on January 16, 2025, with a final expiration date of September 8, 2027, and can reach out to NIH Grants Information at grantsinfo@nih.gov for further inquiries.
    Investigator-Initiated Research in Genomics and Health Equity (R01 Clinical Trial Optional)
    National Institutes of Health
    The National Institutes of Health (NIH) has announced a funding opportunity titled "Investigator-Initiated Research in Genomics and Health Equity" (RFA-HG-23-017), aimed at promoting health equity through innovative genomic research. This initiative encourages applicants to propose research that enhances the understanding and application of genomics across diverse U.S. populations, with a particular focus on engaging underrepresented groups and incorporating a Plan for Enhancing Diverse Perspectives (PEDP). The NIH plans to commit significant funds, with a maximum budget of $500,000 in direct costs per year for projects lasting four to five years, and applications are due by July 8, 2025. Interested applicants can reach out to NIH Grants Information at grantsinfo@nih.gov for further inquiries and are encouraged to review the full announcement at NIH Grants.
    Genomic Community Resources (U24 Clinical Trial Not Allowed)
    National Institutes of Health
    The National Institutes of Health (NIH) has announced a funding opportunity (PAR-23-124) aimed at supporting the development of genomic community resources through cooperative agreements. This initiative seeks to enhance genomic research by funding projects that demonstrate broad applicability and significant value, focusing on the creation of genomic informatics tools, biological material collections, and community engagement efforts. The funded projects will play a crucial role in advancing both basic and clinical genomics research, with awards potentially lasting up to five years. Interested applicants, including a diverse range of organizations such as higher education institutions and nonprofits, must submit their applications by January 25, 2026, and can find further details and submission guidelines at NIH Grants. For inquiries, applicants can contact NIH Grants Information at grantsinfo@nih.gov.
    Investigator-Initiated Research in Genomics and Health Equity (R21 Clinical Trial Optional)
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity titled "Investigator-Initiated Research in Genomics and Health Equity (R21 Clinical Trial Optional)" aimed at supporting small-scale research projects that enhance health equity through genomic research. The initiative seeks to develop innovative approaches and metrics to ensure the equitable application of genomics in improving health outcomes for U.S. populations, particularly focusing on historically underrepresented groups in biomedical research. Eligible applicants include a wide range of organizations, such as higher education institutions, nonprofit organizations, and state governments, with funding available up to $200,000 annually for a maximum of two years. Interested parties should submit their applications by July 8, 2025, and can direct inquiries to NIH Grants Information at grantsinfo@nih.gov or visit the opportunity's webpage for more details at https://grants.nih.gov/grants/guide/rfa-files/RFA-HG-23-018.html.