The Department of Health and Human Services, through the NIH, invites applications for the INCLUDE Project, focusing on generating integrated genomic and multi-omics data related to Down syndrome. This initiative aims to elucidate the molecular mechanisms behind health issues associated with Down syndrome, which affects a significant number of individuals annually. The program encourages biospecimen submissions for diverse omics analyses, including genome sequencing and other advanced techniques, with a strong emphasis on underrepresented groups. No direct funding will be provided to applicants under this notice; instead, selected cohorts will gain access to NIH resources to support data generation. Overall, the project seeks to enhance understanding of Down syndrome's co-occurring conditions and improve health outcomes for affected individuals through collaborative efforts with designated sequencing centers. Key dates for application submissions are outlined, with a project period not exceeding one year. Eligibility encompasses various institutions and organizations, emphasizing the importance of broad data sharing for research advancement.