The Department of Health and Human Services, through the National Institutes of Health (NIH), has announced a funding opportunity titled "Development of Animal Models and Related Biological Materials for Down Syndrome Research" (FOA Number PAR-23-067). This initiative aims to foster innovative and exploratory research to enhance the understanding of Down syndrome (DS) by developing new animal models, genetic resources, and informatics technologies. The INCLUDE Project seeks to identify and address gaps in existing DS research, focusing on co-occurring conditions such as autism, cognitive decline, and cardiovascular issues. Eligible applicants include higher education institutions, non-profits, and government entities, with grants allowing for up to $200,000 in direct costs annually, for a total of $275,000 over two years. The R21 grant type is specifically designed to encourage high-risk, high-reward research projects that could lead to significant advancements without the need for extensive preliminary data. Applications must adhere to strict guidelines regarding submission processes, including electronic submission via Grants.gov and compliance with NIH policies on data management. Review criteria will consider innovation, significance, approach, and investigator qualifications. This announcement underscores NIH's commitment to improving health outcomes and quality of life for individuals with Down syndrome through collaborative and rigorous scientific inquiry.