The National Institutes of Health (NIH) is inviting applications for the Core "Center of Excellence" Grant Program (P30 Clinical Trial Optional), aimed at enhancing research related to substance use, misuse, addiction, and HIV through collaborative interdisciplinary projects. This funding opportunity encourages innovative approaches rather than incremental advancements and is particularly focused on providing opportunities for early-career researchers from underrepresented backgrounds. The initiative seeks to establish collaborative research centers that serve as national resources for substance use research, ensuring diverse perspectives and effective public health impacts. Applications are due by November 17, 2025, and interested parties can find more information and submit inquiries via grantsinfo@nih.gov or by visiting the program's webpage at https://grants.nih.gov/grants/guide/pa-files/PAR-23-049.html.