The National Institute on Drug Abuse (NIDA) is inviting grant applications for Program Project Grants (P01) with an optional clinical trial component, focusing on multidisciplinary research addressing critical issues related to substance use and its consequences. This opportunity aims to gather collaborative teams to explore areas such as neuroscience, genetics, HIV/AIDS, and health services that affect individuals with substance use disorders. Applications must include at least three interrelated research projects demonstrating scientific merit and similar thematic goals, supported by an administrative core. The application timeline indicates several submission deadlines in 2023 and 2024, with a maximum project duration of up to five years and no budget limits specified. A critical component of the application is the Plan for Enhancing Diverse Perspectives (PEDP) to promote inclusivity and address disparities in the research context. Eligible applicants include various entities, such as higher education institutions and nonprofit organizations. The document outlines comprehensive instructions on applications, evaluations, eligibility, and submission processes, emphasizing adherence to NIH guidelines throughout. This funding opportunity reflects NIH's commitment to advancing addiction research by fostering collaboration and innovation across multiple disciplines.