The National Institutes of Health is offering a grant opportunity titled "Understanding Mechanisms and Outcomes of Trained Immunity (R21 Clinical Trial Not Allowed)". This grant aims to support research that improves understanding of basic mechanisms and biomarkers of trained immunity, as well as the functional implications of trained immunity. The research should focus on immune system development and function, immunity to vaccines or natural infections, or allergic diseases, autoimmunity, or rejection of organ/tissue/cell transplantation. The grant does not require cost sharing or matching. The maximum award ceiling is $275,000. Other eligible applicants include Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions, Eligible Agencies of the Federal Government, Faith-based or Community-based Organizations, Hispanic-serving Institutions, Historically Black Colleges and Universities, Indian/Native American Tribal Governments, Non-domestic (non-U.S.) Entities, Regional Organizations, Tribally Controlled Colleges and Universities, and U.S. Territories or Possessions. The closing date for applications is January 7, 2027. For more information and to apply, visit the following link: Understanding Mechanisms and Outcomes of Trained Immunity Grant. For any inquiries, contact NIH Grants Information at grantsinfo@nih.gov.