The National Institutes of Health (NIH) is preparing to publish a Notice of Funding Opportunity (NOFO) titled "Causal Hypotheses on the Oral-Systemic Health Impacts of Human Behaviors among People with Chronic Conditions." This initiative aims to solicit innovative research proposals that explore the causal factors influencing human behaviors and their subsequent impacts on oral-systemic health, particularly for individuals with chronic conditions. The research is expected to contribute to the understanding of various biological, biopsychosocial, and environmental factors that affect health outcomes, with a focus on developing projects that can lead to clinical trials for prevention and management of dental and craniofacial conditions. Interested small businesses are encouraged to begin forming collaborations and developing proposals, with the estimated synopsis posting date set for March 2, 2026, and a projected award date of April 1, 2027. For further inquiries, potential applicants can contact William Elwood, PhD, at william.elwood@nih.gov or by phone at 301-402-0116.