Dental Primary Care Practice-Based Research Network: Clinical Trial or Observational Study Planning and Implementation Cooperative Agreement
ID: 360375Type: Posted
Overview

Buyer

National Institutes of Health (HHS-NIH11)

Eligible Applicants

Others

Funding Category

Health

Funding Instrument

Cooperative Agreement

Opportunity Category

Discretionary

Cost Sharing or Matching Requirement

Yes

Original Source

https://grants.gov/search-results-detail/360375
Timeline
    Description

    The National Institutes of Health (NIH) is offering a cooperative agreement opportunity titled "Dental Primary Care Practice-Based Research Network: Clinical Trial or Observational Study Planning and Implementation." This initiative aims to support clinical trials and large observational studies conducted within a Dental Primary Care Practice-Based Research Network (PBRN), focusing on integrating oral health care into overall medical care, including screening for medical conditions and appropriate referrals. The opportunity is particularly relevant for oral health practitioners interested in utilizing the PBRN infrastructure for research, with an expected three awards anticipated. Interested applicants can reach out to Dena Fischer at dena.fischer@nih.gov or by phone at 301-594-4876 for further information. The estimated synopsis post date is March 2, 2026, with applications expected to close on September 7, 2026, and awards projected for April 30, 2027.

    Point(s) of Contact
    Dena Fischer, DDS, MSD, MS
    (301) 594-4876
    dena.fischer@nih.gov
    Files
    No associated files provided.
    Similar Opportunities
    Dental Primary Care Practice-Based Research Network: Coordinating Center
    National Institutes of Health
    The National Institutes of Health (NIH) is announcing a funding opportunity for the establishment of a Coordinating Center as part of the Dental Primary Care Practice-Based Research Network (PBRN). This initiative aims to enhance practice-based research by supporting the infrastructure necessary for planning and implementing multiple observational studies and clinical trials focused on integrating oral health care into overall medical care. The Coordinating Center will manage a network membership database and develop centralized data management systems that facilitate innovative electronic data capture methods, allowing for the collection of research participant data outside of traditional in-office visits. Interested applicants can reach out to Dena Fischer at dena.fischer@nih.gov or by phone at 301-594-4876 for further information. The estimated synopsis post date is March 2, 2026, with a closing date anticipated on June 5, 2026, and the award date projected for April 30, 2027.
    Dental Primary Care Practice-Based Research Network: Administrative and Resource Center
    National Institutes of Health
    The National Institutes of Health (NIH) is announcing a funding opportunity for the establishment of a Dental Primary Care Practice-Based Research Network (PBRN) through a cooperative agreement aimed at creating an Administrative and Resource Center (ARC). The ARC will facilitate the planning and implementation of observational studies and clinical trials focused on integrating oral health care into overall medical care, thereby promoting whole-person health. This initiative is crucial for enhancing research capabilities in dental primary care settings and will involve recruiting practitioners, managing a single Institutional Review Board (IRB), and providing necessary training for study participation across various U.S. regions. Interested applicants can reach out to Dena Fischer at dena.fischer@nih.gov or call 301-594-4876 for further information. The estimated synopsis post date is March 2, 2026, with applications expected to be solicited by May 25, 2026, and the anticipated award date is April 30, 2027.
    NIDCR Prospective Observational or Biomarker Validation Study Cooperative Agreement
    National Institutes of Health
    The National Institutes of Health (NIH) is announcing a forthcoming opportunity for a cooperative agreement focused on prospective observational or biomarker validation studies through the National Institute of Dental and Craniofacial Research (NIDCR). This initiative aims to solicit applications for studies that involve the prospective collection or continued analysis of data and biospecimens, with an emphasis on well-designed clinical studies that can enhance understanding and improve dental, oral, and craniofacial health. Such studies are crucial for assessing exposure and its relationship to disease development, as well as validating biomarkers for diagnosis and treatment response. While applications are not currently being accepted, interested investigators are encouraged to prepare collaborative proposals in anticipation of the opportunity, which is expected to be formally announced in November 2025, with a closing date for submissions in February 2026. For further inquiries, potential applicants can contact Dr. Lorena Baccaglini at lorena.baccaglini@nih.gov or by phone at 301-435-7908.
    Community Based Participatory Research To Advance DAta and Practice Transformation (ADAPT) For Optimizing Oral Health For All Across the Lifespan (UG3/UH3 Clinical Trial Optional)
    National Institutes of Health
    The National Institutes of Health (NIH) is announcing a funding opportunity titled "Community Based Participatory Research To Advance DAta and Practice Transformation (ADAPT) For Optimizing Oral Health For All Across the Lifespan," aimed at soliciting cooperative agreement research applications. This initiative seeks to evaluate, implement, and test population-based interventions that promote the integration of services and address social and chronic disease risk factors contributing to oral health disparities in communities. The funded projects will form a Community-Based Participatory Research Consortium, collaborating with the NIH Community Engagement Alliance and the Science Collaborative for Health Disparities and Artificial Intelligence Reduction of Errors platform. Interested applicants, particularly small businesses with expertise in population-based interventions, should prepare for the application process, which is expected to open following the estimated synopsis post date of July 3, 2025, with a closing date of October 7, 2025. For further inquiries, potential applicants can contact Hiroko Iida at hiroko.iida@nih.gov or by phone at 301-594-7404.
    NIDCR Drug, Biologic, Device and/or Procedure Intervention Clinical Trial Planning and Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Required)
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity through the NIDCR Drug, Biologic, Device, and Procedure Intervention Clinical Trial Planning and Implementation Cooperative Agreement, designated as UG3/UH3. This initiative aims to support the planning and execution of clinical trials that enhance dental, oral, and craniofacial health, utilizing a two-phased approach: a one-year UG3 planning phase followed by a potential five-year UH3 implementation phase. Eligible applicants include higher education institutions, nonprofits, and local or state governments, with a focus on proposals that test FDA-regulated products and involve significant NIH engagement. Interested parties should note that the application deadline is January 6, 2028, and can find further details and contact information at grantsinfo@nih.gov or through the provided link to the full opportunity announcement at https://grants.nih.gov/grants/guide/pa-files/PAR-25-057.html.
    NIDCR Prospective Observational or Biomarker Validation Study Cooperative Agreement (U01 Clinical Trial Not Allowed)
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity through the National Institute of Dental and Craniofacial Research (NIDCR) for investigator-initiated observational studies or biomarker validation studies that require prospective data collection. This cooperative agreement aims to support research that enhances oral health by generating robust clinical data and validating biomarkers with established preliminary data. The funding is available for projects up to five years, contingent upon NIH appropriations, and emphasizes the significance of the proposed research and the investigator's capability. Interested applicants can find more information and application guidelines at the provided link, with the application due date set for May 7, 2026, and inquiries directed to grantsinfo@nih.gov.
    NIDCR Behavioral and Social Intervention Clinical Trial Planning and Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Required)
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity titled "NIDCR Behavioral and Social Intervention Clinical Trial Planning and Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Required)" aimed at supporting the planning and implementation of clinical trials focused on behavioral and social interventions related to dental, oral, and craniofacial health. This initiative consists of a two-phase approach: the UG3 phase, which allows for up to two years of planning, and the UH3 phase, which can extend up to five years for clinical trial execution, contingent upon meeting specific scientific milestones. This grant is crucial for advancing research methodologies in dental and oral health, particularly in addressing health disparities, and is open to a diverse range of applicants, including higher education institutions and community organizations. Interested parties should note that the application deadline is January 6, 2028, with an award ceiling of $500,000, and can direct inquiries to grantsinfo@nih.gov for further information.
    Continuation or Revision of NIDCR Clinical Trial Planning and Implementation Cooperative Agreement (UH3 Clinical Trial Required)
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity for the continuation or revision of clinical trials under the National Institute of Dental and Craniofacial Research (NIDCR) through a UH3 Exploratory/Developmental Cooperative Agreement. This initiative aims to support competing renewals or competitive revisions of ongoing clinical trials that focus on dental, oral, and craniofacial health, emphasizing the importance of structured data generation in advancing healthcare research. Eligible applicants include a wide range of institutions, such as public and private entities, nonprofits, and government organizations, with the application deadline set for January 6, 2028. Interested parties can find more information and contact NIH Grants Information at grantsinfo@nih.gov for inquiries regarding the application process.
    NIDCR Small Research Grants for Dental, Oral, and Craniofacial Health-related Data Analyses and Statistical or Computational Methodology Development (R03 Clinical Trial Not Allowed)
    National Institutes of Health
    The National Institutes of Health (NIH) is announcing a forthcoming opportunity for small businesses to apply for the NIDCR Small Research Grants aimed at dental, oral, and craniofacial health-related data analyses and the development of statistical or computational methodologies. This grant will support meritorious research projects that propose secondary analyses of existing databases or the development of novel analytical approaches, although applications are not currently being solicited. The initiative is crucial for advancing research in dental and craniofacial health, encouraging investigators to prepare collaborative and responsive projects ahead of the official announcement. Interested applicants can reach out to Lorena Baccaglini, DDS, MS, PhD, at lorena.baccaglini@nih.gov or by phone at 301-435-7908 for further information, with the estimated synopsis posting date set for June 16, 2025, and the application deadline anticipated for October 16, 2025.
    Causal Hypotheses on the Oral-Systemic Health Impacts of Human Behaviors among People with Chronic Conditions
    National Institutes of Health
    The National Institutes of Health (NIH) is preparing to publish a Notice of Funding Opportunity (NOFO) titled "Causal Hypotheses on the Oral-Systemic Health Impacts of Human Behaviors among People with Chronic Conditions." This initiative aims to solicit innovative research proposals that explore the causal factors influencing human behaviors and their subsequent impacts on oral-systemic health, particularly for individuals with chronic conditions. The research is expected to contribute to the understanding of various biological, biopsychosocial, and environmental factors that affect health outcomes, with a focus on developing projects that can lead to clinical trials for prevention and management of dental and craniofacial conditions. Interested small businesses are encouraged to begin forming collaborations and developing proposals, with the estimated synopsis posting date set for March 2, 2026, and a projected award date of April 1, 2027. For further inquiries, potential applicants can contact William Elwood, PhD, at william.elwood@nih.gov or by phone at 301-402-0116.