The National Institutes of Health (NIH) is inviting proposals for the Phased Research to Support Substance Use Epidemiology, Prevention, and Services Studies (R61/R33 Clinical Trials Optional) grant opportunity. This initiative aims to advance translational research that addresses the public health burden of substance use through innovative studies that may begin without preliminary data, utilizing a phased approach for planning and implementation. The program encourages community engagement and requires applicants to submit a Plan for Enhancing Diverse Perspectives (PEDP) as part of the review process. Funding amounts are capped at $350,000 per year for the R61 phase and $750,000 for the R33 phase, with applications due by February 14, 2024. For further inquiries, interested parties can contact NIH Grants Information at grantsinfo@nih.gov or visit the opportunity's webpage at https://grants.nih.gov/grants/guide/pa-files/PAR-24-062.html.