Complement-ARIE New Approach Methodologies (NAMs) Technology Development Centers (UM1 Clinical Trial Optional)
ID: 357631Type: Posted
Overview

Buyer

National Institutes of Health (HHS-NIH11)

Eligible Applicants

Others

Funding Category

Health

Funding Instrument

Cooperative Agreement

Opportunity Category

Discretionary

Cost Sharing or Matching Requirement

Yes

Original Source

https://grants.gov/search-results-detail/357631

Additional Information

http://grants.nih.gov/grants/guide/rfa-files/RFA-RM-24-010.html
Timeline
    Description

    The National Institutes of Health (NIH) is inviting applications for funding under the Notice of Funding Opportunity (NOFO) aimed at establishing Comprehensive New Approach Methodologies (NAMs) Technology Development Centers through its Complement Animal Research In Experimentation (Complement-ARIE) program. The initiative seeks to expedite the development and validation of human-based NAMs to enhance biomedical research models, with a focus on innovative combinatorial approaches that increase biological complexity and promote data sharing in accordance with FAIR principles. This program is significant as it aims to reshape biomedical research paradigms by reducing reliance on animal testing and supporting personalized medicine. Funding is set at approximately $18 million per year, with a maximum budget of $2 million per project over five years, and applications are due by February 28, 2025. For further inquiries, interested parties can contact NIH Grants Information at grantsinfo@nih.gov.

    Point(s) of Contact
    grantsinfo@nih.gov
    Files
    Title
    Posted
    RFA-RM-24-010-Full-Announcement.html
    RFA-RM-24-010.html
    The National Institutes of Health (NIH) is inviting applications for funding under the Notice of Funding Opportunity (NOFO) aimed at establishing Comprehensive New Approach Methodologies (NAMs) Technology Development Centers through its Complement Animal Research In Experimentation (Complement-ARIE) program. This initiative seeks to expedite the development and validation of human-based NAMs to enhance biomedical research models, ultimately supporting personalized medicine and improved therapeutic strategies. The program prioritizes innovative combinatorial NAMs, emphasizing biological complexity and data sharing according to FAIR principles. Successful proposals must demonstrate engagement across multiple disciplines and include a Plan for Enhancing Diverse Perspectives (PEDP). Funding is set at approximately $18 million per year for both new and optional clinical trial applications, with a maximum budget of $2 million per project over five years. Key activities include the establishment of core facilities for administration, data collection, and bioinformatics, alongside training and outreach initiatives aimed at bolstering public understanding of NAMs. Applicants are encouraged to incorporate population diversity in research designs to ensure that NAMs reflect a wide array of human health variables. Overall, the Complement-ARIE program aspires to reshape biomedical research paradigms by integrating advanced methodologies that reduce reliance on animal testing, aligning with recent federal regulatory shifts.
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