Development of Resources and Technologies for Enhancing Rigor, Reproducibility, and Translatability of Animal Models in Biomedical Research (R01)
ID: 344232Type: Posted
Overview

Buyer

National Institutes of Health (HHS-NIH11)

Eligible Applicants

Others

Funding Category

Health

Funding Instrument

Grant

Opportunity Category

Discretionary

Cost Sharing or Matching Requirement

Yes
Timeline
    Description

    The National Institutes of Health (NIH), through the Office of Research Infrastructure Programs (ORIP), has announced a funding opportunity for the development of resources and technologies aimed at enhancing the rigor, reproducibility, and translatability of animal models in biomedical research. This R01 grant encourages hypothesis-driven research projects that address validation gaps in animal models relevant to multiple NIH Institutes and Centers, emphasizing the need for advanced technologies applicable across various organ systems and diseases. The initiative is crucial for overcoming barriers in animal research, ultimately fostering improved clinical outcomes. Interested applicants, including a diverse range of institutions, must submit their proposals by July 5, 2025, with project durations not exceeding five years. For further inquiries, applicants can contact NIH Grants Information at grantsinfo@nih.gov.

    Point(s) of Contact
    Files
    Title
    Posted
    The National Institutes of Health (NIH), through the Office of Research Infrastructure Programs (ORIP), has issued a Funding Opportunity Announcement (FOA) aimed at enhancing the rigor, reproducibility, and translatability of animal models in biomedical research. The R01 grant, titled “Development of Resources and Technologies for Enhancing Rigor, Reproducibility, and Translatability of Animal Models,” encourages hypothesis-driven projects that address gaps in validating animal models relevant to multiple NIH Institutes and Centers. Key dates for application submissions span from November 22, 2022, to July 6, 2025, with proposed project durations not exceeding five years. The FOA emphasizes the need for advanced technologies, tools, and resources applicable to various organ systems and diseases. Eligible applicants include a diverse range of institutions, from higher education to non-profit organizations. Projects focusing on high-efficiency gene editing, biosensors, and AI tools for data integration are encouraged, whereas applications concentrated solely on specific diseases or applications predominantly relevant to one NIH Institute will be deemed nonresponsive. Applicants are advised to communicate with ORIP staff prior to submission to ensure alignment with the FOA's goals. The announcement underscores NIH’s commitment to addressing critical barriers in animal research to foster improved clinical outcomes.
    Similar Opportunities
    Development of Resources and Technologies for Enhancing Rigor, Reproducibility, and Translatability of Animal Models in Biomedical Research (R01 Clinical Trial Not Allowed)
    National Institutes of Health
    The National Institutes of Health (NIH) is inviting research project applications for the grant opportunity titled "Development of Resources and Technologies for Enhancing Rigor, Reproducibility, and Translatability of Animal Models in Biomedical Research." This initiative aims to support hypothesis-driven projects that develop technologies and resources to improve the validity and applicability of animal research across multiple organ systems and diseases, addressing critical gaps identified in previous workshops. The funding is crucial for enhancing research methodologies in biomedical applications, with awards available for up to five years and a maximum budget of $500,000, requiring pre-approval for requests exceeding this amount. Interested applicants can find more information and application guidelines at the NIH Grants Information website or contact grantsinfo@nih.gov, with the application deadline set for September 7, 2025.
    Development of Resources and Technologies for Enhancing Rigor, Reproducibility, and Translatability of Animal Models in Biomedical Research (R24 Clinical Trials Not Allowed)
    National Institutes of Health
    The National Institutes of Health (NIH), through the Office of Research Infrastructure Programs (ORIP), is offering a funding opportunity (PAR-23-039) aimed at developing resources and technologies to enhance the rigor, reproducibility, and translatability of animal models in biomedical research. This initiative encourages applicants to propose broadly applicable technologies that address critical gaps in animal research, focusing on various animal models and ensuring that the proposed resources have significant impact across multiple NIH Institutes and Centers. Successful proposals should demonstrate the necessity and broad applicability of the resources, with project durations of up to four years and no budget limits, although requests exceeding $500,000 require prior approval. Interested applicants can find more information and submit inquiries via email to grantsinfo@nih.gov, with the application deadline set for May 25, 2025.
    Resource-Related Research Projects for Development of Animal Models and Related Materials (R24 Clinical Trials Not-Allowed)
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity titled "Resource-Related Research Projects for Development of Animal Models and Related Materials," aimed at advancing research that develops and enhances animal models relevant to human diseases. The initiative seeks applications that demonstrate the need for and potential impact of broadly applicable resources across multiple NIH Institutes and Centers, emphasizing projects that address diseases affecting multiple body systems rather than those focused on specific diseases or singular NIH interests. Eligible applicants include higher education institutions, nonprofit organizations, and government agencies, with funding available up to $5 million per year. The application deadline is set for January 25, 2025, and interested parties can reach out to NIH Grants Information at grantsinfo@nih.gov for further inquiries.
    Development of Animal Models and Related Biological Materials for Research (R21 Clinical Trial Not Allowed)
    National Institutes of Health
    The National Institutes of Health (NIH) has announced a Notice of Funding Opportunity (NOFO) for the development of animal models and related biological materials for research, designated as an R21 Exploratory/Developmental Research Grant. This funding initiative aims to support innovative projects that enhance, characterize, and preserve animal models relevant to human health and diseases, with a focus on studies that encompass multiple body systems or disease categories rather than single-disease research. The total funding available is $200,000, with a project period limited to two years, and applications are due by January 7, 2028. Interested applicants can find more information and guidance by contacting NIH Grants Information at grantsinfo@nih.gov or visiting the official announcement at https://grants.nih.gov/grants/guide/pa-files/PAR-25-273.html.
    Research Projects to Enhance Applicability of Mammalian Models for Translational Research (R01 Clinical Trial Not Allowed)
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity titled "Research Projects to Enhance Applicability of Mammalian Models for Translational Research (R01 Clinical Trial Not Allowed)," aimed at improving the utility of mammalian cancer models in translational research. This initiative seeks projects that enhance the accuracy and application of models, such as organoids and tumoroids, to better represent human biology and inform clinical practices, addressing current limitations and fostering innovation in cancer research methodologies. Eligible applicants include a diverse range of organizations, such as higher education institutions and community-based organizations, with a maximum funding amount of $499,000 per year for projects not exceeding five years. Interested parties should submit their applications through Grants.gov, with deadlines beginning January 5, 2025, and can direct inquiries to grantsinfo@nih.gov for further information.
    Research Projects to Enhance Applicability of Mammalian Models for Translational Research (R01 Clinical Trial Not Allowed)
    National Institutes of Health
    The National Institutes of Health (NIH) has announced a funding opportunity titled "Research Projects to Enhance Applicability of Mammalian Models for Translational Research (R01 Clinical Trial Not Allowed)." This initiative invites applications aimed at improving the utility of mammalian cancer models, including organoids and tumoroids, to better represent human biology and address translational deficiencies in existing models. The funding seeks to advance cancer research by fostering innovative approaches to validate these models and enhance their clinical relevance, ultimately aiming to improve patient outcomes. Eligible applicants can receive up to $499,000 per year for a maximum of five years, with applications due by September 7, 2026. For further inquiries, interested parties can contact NIH Grants Information at grantsinfo@nih.gov or visit the additional information link at https://grants.nih.gov/grants/guide/pa-files/PAR-23-281.html.
    Utilizing Equipment to Study Environmental Extrinsic Factors and Enhance Rigor and Reproducibility of Animal Research (R24, Clinical Trials Not-Allowed)
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a grant opportunity titled "Utilizing Equipment to Study Environmental Extrinsic Factors and Enhance Rigor and Reproducibility of Animal Research (R24, Clinical Trials Not-Allowed)." This funding initiative aims to support research that systematically investigates the impact of environmental extrinsic factors, such as temperature and humidity, on animal research outcomes, with the goal of improving the rigor and reproducibility of such studies. Eligible applicants include a wide range of organizations, including higher education institutions and various government entities, with a maximum funding amount of $400,000 available for projects lasting up to four years. Interested parties should submit their applications by September 25, 2026, and can direct inquiries to NIH Grants Information at grantsinfo@nih.gov or visit the opportunity's webpage for more details at https://grants.nih.gov/grants/guide/pa-files/PAR-24-167.html.
    Animal and Biological Material Resource Centers (P40) (Clinical Trials Not-Allowed)
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a grant opportunity titled "Animal and Biological Material Resource Centers" (P40) aimed at supporting specialized colonies of laboratory animals and related resources to enhance scientific rigor and reproducibility in biomedical research. This funding initiative encourages applicants to propose centers that not only continue existing resources but also develop new ones based on the needs of the biomedical research community, providing unique animal models, informatics tools, and biological materials applicable across multiple NIH Institutes. The total funding commitment is anticipated to be $1.3 million over three years, with at least two grants awarded annually, and interested applicants must adhere to strict application guidelines, with submissions accepted until January 28, 2025. For further inquiries, applicants can contact NIH Grants Information at grantsinfo@nih.gov.
    Innovation Grants to Nurture Initial Translational Efforts (IGNITE): Development and Validation of Model Systems to Facilitate Neurotherapeutic Discovery (R61/R33 Clinical Trial Not Allowed)
    National Institutes of Health
    The National Institutes of Health (NIH) has announced a funding opportunity titled "Innovation Grants to Nurture Initial Translational Efforts (IGNITE)" aimed at developing and validating model systems for neurotherapeutic discovery. This initiative encourages proposals for animal models or ex vivo systems that accurately replicate the characteristics of specific neurological or neuromuscular disorders, with the goal of enhancing the translational relevance of these models to improve drug development processes. The program utilizes a phased award mechanism (R61/R33) and requires collaboration with clinical experts, along with a Plan for Enhancing Diverse Perspectives (PEDP) to promote inclusivity in research. The total funding available is $750,000 over three years, with a maximum of $499,000 in direct costs per year. Key submission dates begin with the earliest application due date of January 18, 2025. For further inquiries, applicants can contact NIH Grants Information at grantsinfo@nih.gov.
    Complement-ARIE New Approach Methodologies (NAMs) Technology Development Centers (UM1 Clinical Trial Optional)
    National Institutes of Health
    The National Institutes of Health (NIH) is inviting applications for funding under the Notice of Funding Opportunity (NOFO) aimed at establishing Comprehensive New Approach Methodologies (NAMs) Technology Development Centers through its Complement Animal Research In Experimentation (Complement-ARIE) program. The initiative seeks to expedite the development and validation of human-based NAMs to enhance biomedical research models, with a focus on innovative combinatorial approaches that increase biological complexity and promote data sharing in accordance with FAIR principles. This program is significant as it aims to reshape biomedical research paradigms by reducing reliance on animal testing and supporting personalized medicine. Funding is set at approximately $18 million per year, with a maximum budget of $2 million per project over five years, and applications are due by February 28, 2025. For further inquiries, interested parties can contact NIH Grants Information at grantsinfo@nih.gov.