The National Institutes of Health (NIH), through the Office of Research Infrastructure Programs (ORIP), has announced a funding opportunity for the development of resources and technologies aimed at enhancing the rigor, reproducibility, and translatability of animal models in biomedical research. This R01 grant encourages hypothesis-driven research projects that address validation gaps in animal models relevant to multiple NIH Institutes and Centers, emphasizing the need for advanced technologies applicable across various organ systems and diseases. The initiative is crucial for overcoming barriers in animal research, ultimately fostering improved clinical outcomes. Interested applicants, including a diverse range of institutions, must submit their proposals by July 5, 2025, with project durations not exceeding five years. For further inquiries, applicants can contact NIH Grants Information at grantsinfo@nih.gov.