The National Institutes of Health (NIH) is offering the Stephen I. Katz Early Stage Investigator Research Project Grant (R01 Clinical Trial Not Allowed) to support innovative research projects led by Early Stage Investigators (ESIs). This grant aims to encourage ESIs to explore new research directions without the necessity of preliminary data, requiring applications to demonstrate a clear deviation from prior research and align with the scientific missions of participating NIH Institutes and Centers. The initiative emphasizes workforce diversity and is part of NIH’s commitment to advancing health research and innovation, with applications undergoing a peer review process based on significance, investigator qualifications, innovation, and overall approach. Interested applicants can find more information and submit their proposals by December 28, 2026, and should direct inquiries to grantsinfo@nih.gov.