The National Human Genome Research Institute (NHGRI) within the Department of Health and Human Services has issued a funding opportunity under the title "Supporting Talented Early Career Researchers in Genomics." This R01 Clinical Trial Optional funding aims to support innovative research projects led by Early Stage Investigators (ESIs) who have a career interest in genomics. The initiative encourages diverse applicants from various backgrounds to propose research that aligns with NHGRI's mission, focusing on genomic sciences, medicine, data science, and the ethical implications of genomics. Key details include a funding commitment of at least $2 million over several years, awarding 3-5 grants, with individual budgets capped at $400,000 annually. Applications must be submitted electronically by set deadlines, with no late submissions accepted. All applications should include a detailed professional development plan, justified institutional support, and a resource sharing plan complying with NIH policies. Review criteria focus on the significance of the research, approach, and the capabilities of the investigator. This funding opportunity reflects a broader initiative to promote the stability and diversity of the biomedical workforce, aligning with NIH’s goals for nurturing early career researchers in critical scientific fields.