The Department of Health and Human Services, in collaboration with several NIH institutes, has released a funding opportunity for Small Grants aimed at new investigators to enhance participation in health-related research. The purpose of this initiative is to support new researchers from diverse and underrepresented backgrounds in biomedical science, particularly those interested in the scientific mission areas of NIDDK, NHGRI, and NIBIB. Grants will fund small-scale projects that foster the transition of these investigators toward research independence. Key details of the announcement include a maximum budget of $125,000 per year for a project period not exceeding three years. Applicants must demonstrate that they have had less than $125,000 in direct costs from combined active research funding. The NOFO encourages proposals addressing health disparities and includes a variety of project types, such as pilot studies and methodology development. Application deadlines commence in early 2025, with specific submission guidelines outlined for grant preparation and eligibility. This funding mechanism exemplifies NIH's commitment to diversifying the scientific workforce while facilitating research addressing complex public health challenges, ultimately driving advancements in health equity and innovation in biomedical research.