The National Institutes of Health (NIH) is offering the Stephen I. Katz Early Stage Investigator Research Project Grant (R01), aimed at supporting innovative research projects by early-stage investigators (ESIs) that signify a substantial change in research direction without the inclusion of preliminary data. This grant specifically targets basic experimental studies involving human participants, requiring applicants to provide a detailed explanation of how their proposed project diverges from their previous work, while aligning with the scientific missions of participating NIH Institutes and Centers. The funding opportunity encourages diversity and aims to stimulate novel approaches in biomedical research, with applications accepted until December 29, 2026. Interested applicants can find more information and contact NIH Grants Information at grantsinfo@nih.gov for inquiries.