The Department of Health and Human Services, under the National Institutes of Health (NIH), issues the NIMHD Exploratory/Developmental Research Grant Program (R21) to enhance minority health and reduce health disparities in the U.S. This program encourages applications for innovative short-term research projects without the need for preliminary data, particularly from early-stage investigators. Eligible research includes biomedical, clinical, and social sciences focusing on NIH-designated health disparity populations such as racial/ethnic minorities and underserved groups. Projects are expected to utilize multi-disciplinary approaches and can fall into three categories: secondary data analysis, development of new methodologies, and pilot testing of interventions. Grants may fund up to $275,000 over two years, with deadlines for applications set for various review cycles until May 2026. Compliance with application instructions is critical for acceptance, with particular emphasis on promoting innovative solutions to pressing health disparities. The announcement stresses the importance of partnerships with organizations and community stakeholders to align research with real-world health challenges.