The National Institutes of Health (NIH), through the National Cancer Institute (NCI), has announced a funding opportunity titled "NCI Clinical and Translational Exploratory/Developmental Studies (R21 Clinical Trial Optional)." This grant aims to support innovative exploratory and developmental research in cancer diagnosis, treatment, imaging, symptom management, and prevention, specifically targeting early-phase clinical studies and novel therapeutic developments. The initiative is particularly significant for advancing cancer research and addressing health disparities, as it encourages projects that may involve considerable risk but have the potential for major breakthroughs in cancer treatment and understanding. Eligible applicants include a wide range of institutions, including educational entities, nonprofits, and foreign organizations, with a funding ceiling of $275,000 over two years. Applications are due by July 1, 2025, and interested parties can find more information and application guidelines at the NIH website or contact the NIH OER Webmaster at OERWebmaster03@od.nih.gov.