The National Institutes of Health (NIH), through the National Institute on Drug Abuse (NIDA), has announced a funding opportunity titled "High Priority HIV and Substance Use Research (R01 Clinical Trial Optional)" aimed at stimulating innovative research at the intersection of HIV and substance use. This initiative invites applications for research projects that explore new avenues for the prevention, treatment, and potential cure of HIV among people who use drugs, requiring detailed research plans and preliminary data that emphasize the connection to substance use. With a total funding allocation of $3.5 million for fiscal years 2022, 2023, and 2024, the NIH expects to award 3-5 grants, and applications are due by August 2, 2024. Interested applicants can find more information and contact the NIH OER Webmaster at OERWebmaster03@od.nih.gov for inquiries.