The National Institutes of Health (NIH) is offering the Directors Transformative Research Awards (R01 Clinical Trial Optional) to support innovative and groundbreaking research that has the potential to significantly advance scientific paradigms and improve health outcomes. This funding opportunity encourages applications from individual scientists or collaborative teams, particularly those from diverse and underrepresented backgrounds, without the requirement for preliminary data, provided they can demonstrate a compelling rationale for their proposed research. The NIH aims to minimize barriers to high-risk, high-reward research, with approximately $8 million available for around seven awards, each with a maximum project period of five years. Interested applicants must submit their proposals by September 4, 2024, and can find additional information and submission guidelines at the NIH grants website or contact grantsinfo@nih.gov for inquiries.