The National Institutes of Health (NIH) is inviting applications for the NCI Outstanding Investigator Award (R35 Clinical Trial Optional), aimed at providing long-term support to accomplished cancer researchers. This grant opportunity encourages innovative, high-risk research that has the potential to lead to significant breakthroughs in biomedical, behavioral, or clinical cancer research, with funding available up to $600,000 in direct costs per year for a maximum of seven years. The program is particularly focused on supporting diverse institutions and underrepresented groups, requiring applicants to demonstrate a strong history of research contributions and commit at least six person-months to their proposed projects. Interested applicants should note that the application deadline is November 7, 2024, and can find further details and guidelines at the provided NIH link or contact the NIH OER Webmaster at OERWebmaster03@od.nih.gov for inquiries.