The National Institutes of Health (NIH) is offering the Trailblazer Award for New and Early Stage Investigators (R21 Clinical Trial Optional), aimed at fostering innovative research that integrates engineering and physical sciences with life and biomedical sciences. This grant opportunity encourages applicants to pursue exploratory, developmental, or high-risk projects without the necessity for preliminary data, thereby promoting creative solutions to unmet biomedical research needs. The award supports a maximum of $400,000 in direct costs over three years, with applications due by January 7, 2026. Interested applicants can find more information and guidelines at the NIH Grants website or contact NIH Grants Information at grantsinfo@nih.gov for further inquiries.